NITROFEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H7Cl2NO3
Molecular Weight	284.095
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CC=C(OC2=CC=C(Cl)C=C2Cl)C=C1

InChI

InChIKey=XITQUSLLOSKDTB-UHFFFAOYSA-N

InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H

HIDE SMILES / InChI

Molecular Formula	C12H7Cl2NO3
Molecular Weight	284.095
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.	2006-03	16214817
Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it.	2006-01	16292552
Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants.	2006-01	16284794
Screening 31 endocrine-disrupting pesticides in water and surface sediment samples from Beijing Guanting reservoir.	2005-12	15982717
Nitrovasodilator responses in pulmonary arterioles from rats with nitrofen-induced congenital diaphragmatic hernia.	2005-11	16291156
Adrenomedullin is up-regulated in nitrofen-induced fetal pulmonary hypoplasia.	2005-10	16226985
Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia.	2005-08	16080930
Fog2 is required for normal diaphragm and lung development in mice and humans.	2005-07	16103912
Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation.	2005-07	15764645
Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia.	2005-04	15852274
Insulinlike growth factor I gene expression is increased in the fetal lung after tracheal ligation.	2005-03	15793718
Expression of vasoactive mediators during mechanical ventilation in nitrofen-induced diaphragmatic hernia in rats.	2005-03	15756563
Pax3 mRNA is decreased in the hearts of rats with experimental diaphragmatic hernia.	2005-03	15616818
Can maternal vitamin e supplementation prevent lung hypoplasia in the nitrofen-induced rat model of congenital diaphragmatic hernia?	2005-03	15611344
Altered expression of angiotensin II receptor subtypes and transforming growth factor-beta in the heart of nitrofen-induced diaphragmatic hernia in rats.	2005-03	15578192
V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals.	2005-02-07	15668106
Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells.	2005-02	15582350
Modulation at a cellular level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4'-diiodobiphenyl (DIB), and nitrofen (NIP).	2005-01-15	15585367
Effect of nitric oxide on the development of nitrofen-induced fetal hypoplastic lung explants.	2005-01	15861370
Differential effects of vitamin A on fetal lung growth and diaphragmatic formation in nitrofen-induced rat model.	2005	15707848
Effect of endocrine disrupting chemicals on lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by mouse macrophages.	2004-07	15256756
The relationship of diaphragmatic defect, liver growth, and lung hypoplasia in nitrofen-induced congenital diaphragmatic hernia in the rat.	2004-07	15221367
Pulmonary vascular morphology in a fetal rabbit model for congenital diaphragmatic hernia.	2004-07	15213901
VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia.	2004-06	15185205
Effect of two nitrogenous diphenyl ether pesticides on mast cell activation.	2004-05-02	15110079
Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay.	2004-05	15253041
Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia.	2004-05	15136996
Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity.	2004-05	14754874
Reductions in the incidence of nitrofen-induced diaphragmatic hernia by vitamin A and retinoic acid.	2004-05	14729516
Vitamin C rescues in part the effects of nitrofen on cultured human pneumocytes.	2004-04	15083329
Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.	2004-04	15064155
The vagus and recurrent laryngeal nerves in experimental congenital diaphragmatic hernia.	2004-04	14758499
Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscles cells in nitrofen-induced congenital diaphragmatic hernia in rats.	2004-03	15088113
Exposure of cardiac fibroblasts to the herbicide nitrofen causes altered interactions with the extracellular matrix.	2004-02	15119844
Effect of epidermal growth factor on pulmonary hypoplasia in experimental diaphragmatic hernia.	2004-01	14694368
Nitrofen-induced congenital diaphragmatic hernia in rat embryo: what model?	2004-01	14694366
Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model.	2003-11	12904592
Fetal heart development in the nitrofen-induced CDH rat model: the role of mechanical and nonmechanical factors.	2003-10	14577066
Prenatal vitamin E improves lung and heart hypoplasia in experimental diaphragmatic [correction of diaphragamatic] hernia.	2003-07	12898160
Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats.	2003-07	12861530
Increased expression of ICAM-1 and VCAM-1 in the lung of nitrofen-induced congenital diaphragmatic hernia in rats.	2003-07	12759764
Expression and activity of matrix metallo proteinases 2 and 9 and their inhibitors in rat lungs during the perinatal period and in diaphragmatic hernia.	2003-06	12746050
The adrenal cortex in experimental congenital diaphragmatic hernia.	2003-05	12720169
Airway smooth muscle changes in the nitrofen-induced congenital diaphragmatic hernia rat model.	2003-05	12612200
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1: expression in the lung of fetal rats with nitrofen-induced diaphragmatic hernia.	2003-04	12721718
Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.	2003-02	12547725
Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia.	2003-02	12547712
The activation of the retinoic acid response element is inhibited in an animal model of congenital diaphragmatic hernia.	2003	12660430
[Nitrofen in food products. DGE information on health-related assessment: which results are significant for current nutrition recommendations?].	2002-08	14603746
Nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether).	2002	15326692

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:56 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:56 GMT 2025`
Record UNII	N71UYG034A
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TOK

Preferred Name

English

NITROFEN

Common Name

English

NITROFEN [ISO]

Common Name

English

NITROFEN [IARC]

Common Name

English

2,4-DICHLORO-1-(4-NITROPHENOXY)BENZENE

Systematic Name

English

NITROFEN [MI]

Common Name

English

NITROFEN [HSDB]

Common Name

English

2,4-DICHLOROPHENYL 4-NITROPHENYL ETHER

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

38201