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Details

Stereochemistry ACHIRAL
Molecular Formula C12H12N.I
Molecular Weight 297.1349
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYPERQUAT IODIDE

SMILES

[I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2

InChI

InChIKey=RFDFRDXIIKROAI-UHFFFAOYSA-M
InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula HI
Molecular Weight 127.9124
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C12H12N
Molecular Weight 170.2304
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Stimulation of the regrowth of MPP+-damaged dopaminergic fibers by the treatment of mesencephalic cultures with basigin.
2001
Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture.
2001
Prosaptide D5, a retro-inverso 11-mer peptidomimetic, rescued dopaminergic neurons in a model of Parkinson's disease.
2001 Apr
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole.
2001 Apr 6
Nitric oxide enhances MPP(+) inhibition of complex I.
2001 Aug 24
MPP(+) downregulates mitochondrially encoded gene transcripts and their activities in dopaminergic neuronal cells: protective role of Bcl-2.
2001 Aug 24
Accumulation of the 1-methyl-4-phenylpyridinium ion in suncus (Suncus murinus) brain: implication for flavin-containing monooxygenase activity in brain microvessels.
2001 Feb
Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters.
2001 Jan
A novel zidovudine uptake system in microglia.
2001 Jan
GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+ -induced apoptosis.
2001 Jul 3
Carrier-mediated processes in blood--brain barrier penetration and neural uptake of paraquat.
2001 Jul 6
Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.
2001 Jun
Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter.
2001 Jun 22
Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4).
2001 Jun 6
Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion.
2001 May
Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium.
2001 Nov 16
1-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation.
2001 Sep
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration.
2001 Sep
Capillary electrophoretic determination of apoptosis of rat cerebellar granule cells induced by 1-methyl-4-phenyl pyridium ion.
2002 Apr
Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.
2002 Apr 1
Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms.
2002 Apr 15
Protection of dopaminergic neurons in primary culture by lisuride.
2002 Feb
Differential expression of Bcl-2 and APP immunoreactivity after intrastriatal injection of MPP+ in the rat.
2002 Feb
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.
2002 Feb 15
Nitric oxide and depolarization induce hydroxyl radical generation.
2002 Jan
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
2002 Jul
Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease.
2002 Jun
Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping.
2002 Jun 14
Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells.
2002 Jun 15
Progressive alteration of neuronal dopamine transporter activity in a rat injured by an intranigral injection of MPP+.
2002 Jun 21
Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells.
2002 Mar
The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells.
2002 Mar 22
Regulation of [(3)H]MPP(+) transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase.
2002 May
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 17 04:21:44 UTC 2022
Edited
by admin
on Sat Dec 17 04:21:44 UTC 2022
Record UNII
N708D004VE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYPERQUAT IODIDE
Common Name English
1-METHYL-4-PHENYLPYRIDINIUM IODIDE
Systematic Name English
PYRIDINIUM, 1-METHYL-4-PHENYL-, IODIDE (1:1)
Systematic Name English
N-METHYL-4-PHENYLPYRIDINIUM IODIDE
Systematic Name English
PYRIDINIUM, 1-METHYL-4-PHENYL-, IODIDE
Systematic Name English
Code System Code Type Description
PUBCHEM
10924457
Created by admin on Sat Dec 17 04:21:44 UTC 2022 , Edited by admin on Sat Dec 17 04:21:44 UTC 2022
PRIMARY
CAS
36913-39-0
Created by admin on Sat Dec 17 04:21:44 UTC 2022 , Edited by admin on Sat Dec 17 04:21:44 UTC 2022
PRIMARY
FDA UNII
N708D004VE
Created by admin on Sat Dec 17 04:21:44 UTC 2022 , Edited by admin on Sat Dec 17 04:21:44 UTC 2022
PRIMARY
EPA CompTox
DTXSID40880040
Created by admin on Sat Dec 17 04:21:44 UTC 2022 , Edited by admin on Sat Dec 17 04:21:44 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE