MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:58:02 GMT 2025` Edited by `admin` on `Tue Apr 01 18:58:02 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	N6M29RDB9E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7

Common Name

English

TAK1

Preferred Name

English

TRANSFORMING GROWTH FACTOR-BETA-ACTIVATED KINASE 1

Common Name

English

MAP3K7

Common Name

English

TGF-BETA-ACTIVATED KINASE 1

Common Name

English

Code System Code Type Description

PHAROS

O43318

Created by admin on Tue Apr 01 18:58:02 GMT 2025 , Edited by admin on Tue Apr 01 18:58:02 GMT 2025

PRIMARY

FDA UNII

N6M29RDB9E

Created by admin on Tue Apr 01 18:58:02 GMT 2025 , Edited by admin on Tue Apr 01 18:58:02 GMT 2025

PRIMARY

UNIPROT

O43318

Created by admin on Tue Apr 01 18:58:02 GMT 2025 , Edited by admin on Tue Apr 01 18:58:02 GMT 2025

PRIMARY

Related Record Type Details


					WC3BRW6EWP

HS-276

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					Z56NTB3YHJ

TAKINIB

INHIBITOR -> TARGET

Comments:

Selective inhibtor prevents TNF.alpha. gene activation.

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_184] [1_187]		T		THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_192] [1_367] [1_389] [1_439] [1_455]		S		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL