Tanruprubart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:50:24 GMT 2025` Edited by `admin` on `Wed Apr 02 02:50:24 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	N5WBB45U8L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ANX-005

Preferred Name

English

Tanruprubart

Official Name

English

ANX005

Code

English

immunoglobulin G4-kappa, anti-[Homo sapiens C1q (complement C1q)], monoclonal antibody (H-gamma4 heavy chain (1-448) [VH Musmus/Homsap (Mus musculus IGHV1-64*01 (82.5%) -(IGHD) -IGHJ4*01 (92.9%) S123>T (116)/Homo sapiens IGHV1-46*01 (79.4%) -(IGHD) -IGHJ

Common Name

English

HUMANISED RECOMBINANT IgG4 KAPPA ANTI C1Q MONOCLONAL ANTIBODY ANX005

Common Name

English

tanruprubart [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

843121

Created by admin on Wed Apr 02 02:50:24 GMT 2025 , Edited by admin on Wed Apr 02 02:50:24 GMT 2025

FDA ORPHAN DRUG

550416

Created by admin on Wed Apr 02 02:50:24 GMT 2025 , Edited by admin on Wed Apr 02 02:50:24 GMT 2025

Code System Code Type Description

SMS_ID

300000005322

Created by admin on Wed Apr 02 02:50:24 GMT 2025 , Edited by admin on Wed Apr 02 02:50:24 GMT 2025

PRIMARY

CAS

2065212-40-8

Created by admin on Wed Apr 02 02:50:24 GMT 2025 , Edited by admin on Wed Apr 02 02:50:24 GMT 2025

PRIMARY

FDA UNII

N5WBB45U8L

Created by admin on Wed Apr 02 02:50:24 GMT 2025 , Edited by admin on Wed Apr 02 02:50:24 GMT 2025

PRIMARY

From	To
1_22	1_96
1_135	3_214
1_148	1_204
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426
2_22	2_96
2_135	4_214
2_148	2_204
2_262	2_322
2_368	2_426
3_134	3_194
3_23	3_88
4_134	4_194
4_23	4_88

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					Z2OXO1W85K

COMPLEMENT COMPONENT 1Q

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					N5WBB45U8L

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL