U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:16:46 GMT 2023
Edited
by admin
on Sat Dec 16 19:16:46 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name dendritic cells from PBMC
Record UNII
N4PY4N58R9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Umitrelimorgene Autodencel
INN  
Official Name English
autologous dendritic cells (DCs) derived from peripheral blood mononuclear cells (PBMCs) obtained from newly diagnosed glioblastoma multiforme patients by apheresis, loaded with two messenger ribonucleic acids (mRNA) encoding (i) human lysosome-associate
Common Name English
umitrelimorgene autodencel [INN]
Common Name English
Code System Code Type Description
FDA UNII
N4PY4N58R9
Created by admin on Sat Dec 16 19:16:46 GMT 2023 , Edited by admin on Sat Dec 16 19:16:46 GMT 2023
PRIMARY
INN
12276
Created by admin on Sat Dec 16 19:16:46 GMT 2023 , Edited by admin on Sat Dec 16 19:16:46 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE EXPANSION BIOLOGICAL IL-4 HUMAN 4I7AHS3FPJ
CULTURE EXPANSION BIOLOGICAL GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR HUMAN KIJ28K7WXF
CULTURE BIOLOGICAL TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (PLASMA DERIVED, SOLUBLE FORM) 4TVX2I407K
CULTURE BIOLOGICAL INTERFERON GAMMA P050J5FWC5
CULTURE BIOLOGICAL DINOPROSTONE K7Q1JQR04M

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
INSERTED GENE EXPRESSION VECTOR Umitrelimorgene autodencel CD-40L M21 mRNA FW8JFG4ZYY
VECTOR EXPRESSED PROTEIN Umitrelimorgene autodencel expressed human lysosomal associated membrane protein 1 (LAMP 1)/human cytomegalovirus (hCMV) 65 kDa matrix protein C4WH2P76QN
VECTOR EXPRESSED PROTEIN CD40 ligand (21-261) J37T4U7EKP
INSERTED GENE EXPRESSION VECTOR Umitrelimorgene autodencel LAMP 1/hCMV) 65 kDa matrix protein mRNA A3BAN3EG8Q
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ENHANCED ACTIVATION BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
PW3DO1LF7X
Unknown Structure
HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR
(not present in database)
ANTIGEN EXPRESSED BIOLOGICAL