Umitrelimorgene Autodencel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 14:35:16 GMT 2025` Edited by `admin` on `Wed Apr 02 14:35:16 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	dendritic cells from pbmc
Record UNII	N4PY4N58R9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Umitrelimorgene Autodencel

Official Name

English

autologous dendritic cells (DCs) derived from peripheral blood mononuclear cells (PBMCs) obtained from newly diagnosed glioblastoma multiforme patients by apheresis, loaded with two messenger ribonucleic acids (mRNA) encoding (i) human lysosome-associate

Preferred Name

English

umitrelimorgene autodencel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

N4PY4N58R9

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

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NCI_THESAURUS

C203189

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

PRIMARY

INN

12276

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

PRIMARY

SMS_ID

300000047278

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

PRIMARY

Related Record Type Details


					N4PY4N58R9

Umitrelimorgene Autodencel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	IL-4 HUMAN	4I7AHS3FPJ
CULTURE	EXPANSION	BIOLOGICAL	GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR HUMAN	KIJ28K7WXF
CULTURE		BIOLOGICAL	TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (PLASMA DERIVED, SOLUBLE FORM)	4TVX2I407K
CULTURE		BIOLOGICAL	INTERFERON GAMMA	P050J5FWC5
CULTURE		BIOLOGICAL	DINOPROSTONE	K7Q1JQR04M

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR	Umitrelimorgene autodencel CD-40L M21 mRNA	FW8JFG4ZYY
VECTOR EXPRESSED PROTEIN	Umitrelimorgene autodencel expressed human lysosomal associated membrane protein 1 (LAMP 1)/human cytomegalovirus (hCMV) 65 kDa matrix protein	C4WH2P76QN
VECTOR EXPRESSED PROTEIN	CD40 ligand (21-261)	J37T4U7EKP
INSERTED GENE EXPRESSION VECTOR	Umitrelimorgene autodencel LAMP 1/hCMV) 65 kDa matrix protein mRNA	A3BAN3EG8Q

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`0X8U3V6C5K` MONOCYTE DIFFERENTIATION ANTIGEN CD14
ANTIGEN EXPRESSED	BIOLOGICAL	`IYZ9TI08W3` B-LYMPHOCYTE ANTIGEN CD19
ENHANCED ACTIVATION	BIOLOGICAL	`P050J5FWC5` INTERFERON GAMMA

ANTIGEN EXPRESSED	BIOLOGICAL	`DI9X6F2RHW` NEURAL CELL ADHESION MOLECULE 1
ANTIGEN EXPRESSED	BIOLOGICAL	`PW3DO1LF7X` HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR (not present in database)
ANTIGEN EXPRESSED	BIOLOGICAL	`ZLW14X2D30` CD3