DAPIROLIZUMAB PEGOL

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	FAB
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	N4606MB5HM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

dapirolizumab pegol [INN]

Preferred Name

English

DAPIROLIZUMAB PEGOL

Official Name

English

CDP-7657

Common Name

English

Dapirolizumab pegol [WHO-DD]

Common Name

English

IMMUNOGLOBULIN FAB' G1-KAPPA PEGYLATED, ANTI-(HOMO SAPIENS CD40LG (CD40 LIGAND, CD40L, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 5, TNFSF5, TUMOR NECROSIS FACTOR RELATED ACTIVATION PROTEIN, TRAP, CD154)), PEGYLATED HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

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Code System

Code

Type

Description

INN

9869

PRIMARY

NCI_THESAURUS

C174737

PRIMARY

SMS_ID

100000171736

PRIMARY

EVMPD

SUB185344

PRIMARY

FDA UNII

N4606MB5HM

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_22	1_95
1_145	1_201
2_23	2_88
2_134	2_194
1_221	2_214

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Related Record

Type

Details


					YUF12AXR3B

CD40 LIGAND SOLUBLE

TARGET -> INHIBITOR


					T169OM1T8L

CD40 LIGAND RECOMBINANT

TARGET -> INHIBITOR

Showing 1 to 2 of 2 entries

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Related Record

Type

Details


					N4606MB5HM

DAPIROLIZUMAB PEGOL

ACTIVE MOIETY

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
PEGYLATION	[1_227]		Cys		METHOXY PEG-20	77U9H6E11K

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 48100 Da (average)
Molecular Formula	CHEMICAL	ESTIMATED C2129H3283N569O674S14

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