Details
Stereochemistry | ACHIRAL |
Molecular Formula | Lu.3NO3 |
Molecular Weight | 360.982 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Lu+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O
InChI
InChIKey=APRNQTOXCXOSHO-UHFFFAOYSA-N
InChI=1S/Lu.3NO3/c;3*2-1(3)4/q+3;3*-1
Molecular Formula | Lu |
Molecular Weight | 174.967 |
Charge | 3 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | NO3 |
Molecular Weight | 62.0049 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Motexafin lutetium is pentadentate aromatic metallotexaphyrin with photosensitizing properties patented by Pharmacyclics, Inc. as anticancer agent that enhances the cytotoxic potential of photodynamic therapy through several mechanisms, including depleting intracellular reducing metabolites that are necessary for repairing the oxidative damage induced by irradiation. Motexafin lutetium catalyzes the oxidation of intracellular reducing metabolites such as ascorbate, glutathione, nicotinamide adenine dinucleotide phosphate, and protein thiols, generating reactive oxygen species in a process known as futile redox cycling. The depletion (through oxidation) of these reducing metabolites removes the substrate necessary in a cell to repair oxidative damage induced by photodynamic therapy and, left unrepaired, such oxidative DNA damage is converted into lethal double-stranded breaks. Motexafin lutetium has the potential to combine the features of selective localization, ability to be activated by deeply penetrating far-red light, low incidence of skin photosensitization and water solubility. The product was in clinical development as a treatment for several types of solid tumors (as Lutrin), age-related macular degeneration (as Optrin), atherosclerosis and prevention of restenosis (as Antrin).
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 13:01:23 GMT 2023
by
admin
on
Sat Dec 16 13:01:23 GMT 2023
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Record UNII |
N434Y42LL8
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Record Status |
Validated (UNII)
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Record Version |
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-
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177678
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24920
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DTXSID60890641
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admin on Sat Dec 16 13:01:23 GMT 2023 , Edited by admin on Sat Dec 16 13:01:23 GMT 2023
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Lutetium(III) nitrate
Created by
admin on Sat Dec 16 13:01:23 GMT 2023 , Edited by admin on Sat Dec 16 13:01:23 GMT 2023
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10099-67-9
Created by
admin on Sat Dec 16 13:01:23 GMT 2023 , Edited by admin on Sat Dec 16 13:01:23 GMT 2023
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233-241-7
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admin on Sat Dec 16 13:01:23 GMT 2023 , Edited by admin on Sat Dec 16 13:01:23 GMT 2023
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N434Y42LL8
Created by
admin on Sat Dec 16 13:01:23 GMT 2023 , Edited by admin on Sat Dec 16 13:01:23 GMT 2023
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PRIMARY |