Oberotatug Ravtansine

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:04:31 GMT 2025` Edited by `admin` on `Wed Apr 02 01:04:31 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	N2Q7V645PL
Record Status	`FAILED`
Record Version

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Name

Type

Language

Oberotatug Ravtansine

Official Name

English

MEN-1309

Preferred Name

English

OBT-076

Code

English

OBEROTATUG RAVTANSINE [USAN]

Common Name

English

OBT076

Code

English

oberotatug ravtansine [INN]

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-15*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.10.10] (26-33.51-60.99-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hing

Common Name

English

MEN1309

Code

English

immunoglobulin G1-kappa, anti-[Homo sapiens LY75 (human lymphocyte antigen 75, C-type lectin domain family 13 member B, CLEC13B, DEC-205, CD205)], Homo sapiens monoclonal antibody; conjugated to ravtansine

Common Name

English

Code System Code Type Description

FDA UNII

N2Q7V645PL

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

USAN

MN-68

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

NCI_THESAURUS

C199080

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

SMS_ID

300000046248

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

CAS

2641919-35-7

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

INN

12296

Created by admin on Wed Apr 02 01:04:31 GMT 2025 , Edited by admin on Wed Apr 02 01:04:31 GMT 2025

PRIMARY

From	To
1_22	1_98
1_146	1_202
1_222	2_222
1_228	2_228
1_231	3_214
1_263	1_323
1_369	1_427
2_22	2_98
2_146	2_202
2_231	4_214
2_263	2_323
2_369	2_427
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Related Record Type Details


					WOB38VS2NI

DM4

CONJUGATE COMPONENT->CONJUGATE

Amount:


					6GJV6H6C9E

Lymphocyte antigen 75

TARGET->LIGAND

Amount:


					DZ67BDC5LF

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					N2Q7V645PL

Oberotatug Ravtansine

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
PROTEIN CONJUGATION		RESIDUE_SPECIFIC	lysine	Amount:	DM4-SPDB-L-LYSINE	6MDF4WB915

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL