9-CARBOXYMETHOXYMETHYLGUANINE

NC1=NC2=C(N=CN2COCC(O)=O)C(=O)N1

InChIKey=MICNQLKUSOVNNG-UHFFFAOYSA-N

InChI=1S/C8H9N5O4/c9-8-11-6-5(7(16)12-8)10-2-13(6)3-17-1-4(14)15/h2H,1,3H2,(H,14,15)(H3,9,11,12,16)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Aciclovir and valaciclovir neurotoxicity in patients with renal failure.	2003 Dec	14605302
High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study.	2003 Jun	12748346
The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.	2006 May	16540518
Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.	2007 Aug	17651180
Development, evaluation and application of an isocratic high-performance liquid chromatography (HPLC) assay for the simultaneous determination of aciclovir and its metabolite 9-carboxymethoxymethylguanine in human serum and cerebrospinal fluid.	2007 Jul	17428641
[Risk of CNS adverse effects of aciclovir and valaciclovir. Watch the renal function in treatment of herpes simplex and herpes zoster].	2007 Jun 13-26	17674672
Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.	2008	18974607
Acyclovir nephrotoxicity: a case report highlighting the importance of prevention, detection, and treatment of acyclovir-induced nephropathy.	2010	20862348

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:45:09 GMT 2023` Edited by `admin` on `Sat Dec 16 09:45:09 GMT 2023`
Record UNII	N28227W35C
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

9-CARBOXYMETHOXYMETHYLGUANINE

Systematic Name

English

ACETIC ACID, ((2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY)-

Systematic Name

English

CMMG

Common Name

English

ACETIC ACID, 2-((2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY)-

Systematic Name

English

Code System Code Type Description

FDA UNII

N28227W35C