Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C13H16N2O8S.H2O |
| Molecular Weight | 378.355 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[H][C@]12SC(COC(N)=O)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(=O)OCOC(C)=O
InChI
InChIKey=ZZFMPSZLBDWBLH-UYQYSZDNSA-N
InChI=1S/C13H16N2O8S.H2O/c1-5(16)8-10(18)15-9(12(19)23-4-22-6(2)17)7(24-11(8)15)3-21-13(14)20;/h5,8,11,16H,3-4H2,1-2H3,(H2,14,20);1H2/t5-,8+,11-;/m1./s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C13H16N2O8S |
| Molecular Weight | 360.34 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/10508039 and http://www.genome.jp/dbget-bin/www_bget?dr:D09849
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/10508039 and http://www.genome.jp/dbget-bin/www_bget?dr:D09849
Ritipenem (FCE 22101), a penem antibiotic, penicillin binding protein inhibitor, is potent against both gram-positive and -negative bacteria, and its acetoxymethyl ester (FCE 22891; ritipenem-acoxil) is orally available. Ritipenem is manufactured by Tanabe Seiyaku in the ritipenem acoxil prodrug form, which can be taken orally. It is not FDA approved in the United States.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2354204 |
0.076 nM [IC50] | ||
Target ID: map00550 |
|||
Target ID: Escherichia coli growth |
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Target ID: Staphylococcus aureus growth |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Unknown Approved UseUnknown |
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| Curative | Unknown Approved UseUnknown |
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| Curative | Unknown Approved UseUnknown |
|||
| Curative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| A study of the pharmacokinetics and tolerability of ritipenem acoxil in healthy volunteers following multiple oral dosing. | 1997 Aug |
|
| MEN 10700, a new penem antibiotic: in-vitro activity and its correlation with beta-lactamase stability, PBP affinity and diffusion through the bacterial cell wall. | 1998 May |
|
| Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae. | 1999 Oct |
Patents
Sample Use Guides
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:26:24 GMT 2023
by
admin
on
Sat Dec 16 05:26:24 GMT 2023
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| Record UNII |
N25O8O59B3
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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76961639
Created by
admin on Sat Dec 16 05:26:24 GMT 2023 , Edited by admin on Sat Dec 16 05:26:24 GMT 2023
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N25O8O59B3
Created by
admin on Sat Dec 16 05:26:24 GMT 2023 , Edited by admin on Sat Dec 16 05:26:24 GMT 2023
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |
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ACTIVE MOIETY |
