Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H12O6 |
Molecular Weight | 180.1559 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)C=O
InChI
InChIKey=GZCGUPFRVQAUEE-ZXXMMSQZSA-N
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4-,5+,6+/m1/s1
Molecular Formula | C6H12O6 |
Molecular Weight | 180.1559 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21707763Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17629262
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21707763
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17629262
Idose is an aldohexose isomeric with galactose. Idose can influence to the stability of phospholipid bilayers and topical application of idose accelerated the skin barrier recovery
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21707763
The effects of topical application of Idose on barrier recovery after barrier disruption by tape stripping were investigated. All experiments were performed on 7- to 10-week-old male hairless mice (HR-1, Hoshino, Japan). Measurement of skin barrier function, disruption of the barrier and application of test samples were carried out under anaesthesia with nembutal.
Permeability barrier function was evaluated by measurement of transepidermal water loss (TEWL) with an electric moisture analyser (Meeco, Warrington, PA, USA). For barrier recovery experiments, skin on both flanks was treated by repeated tape stripping until the TEWL reached 7–10 mg ⁄ cm2 per h. Immediately after tape stripping, 100 mkm of 0.1 m aqueous solution of Idose was applied. TEWL was then measured at the same sites at 1, 3, 6 and 24 h thereafter. Barrier disruption was done between 7:00AM and 8:00AM and the barrier recovery rate was evaluated immediately, to avoid the effect of circadian rhythm.
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:37:47 UTC 2023
by
admin
on
Sat Dec 16 09:37:47 UTC 2023
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Record UNII |
N1T50P1RZ2
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Record Status |
Validated (UNII)
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Record Version |
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111123
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DTXSID901015881
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5978-95-0
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41847-68-1
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m6200
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