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Details

Stereochemistry ACHIRAL
Molecular Formula 2In.3S
Molecular Weight 325.831
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of INDIUM SULFIDE

SMILES

[S--].[S--].[S--].[In+3].[In+3]

InChI

InChIKey=SIXIBASSFIFHDK-UHFFFAOYSA-N
InChI=1S/2In.3S/q2*+3;3*-2

HIDE SMILES / InChI

Molecular Formula In
Molecular Weight 114.818
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HS
Molecular Weight 33.073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Indium is a rare, soft silvery-white metal. It is used in some manufacturing process, butt here is no known biological role for indium in the human body. Although there are claims that indium increases hormone production, stimulates immune system function, and increases energy, there is no reliable scientific evidence to support such claims. In vitro, indium-III salts appears to have cytotoxic activity against melanoma. Indium cation (Indium-III), when complexed with 8-hydroxyquinoline (oxine), has been employed as a radioactive platelet label for thrombus imaging in animals and man. The short half-life (2.8 d) and high yield of gamma photons of 111In make it ideal for in vitro counting and external imaging. Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk. Indium In 111 ProstaScint is also indicated as a diagnostic imaging agent in post-prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation in whom there is a high clinical suspicion of occult metastatic disease.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P06214
Gene ID: 25374.0
Gene Symbol: Alad
Target Organism: Rattus norvegicus (Rat)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Indium In 111 Chloride

Approved Use

Indium In 111 Chloride Sterile Solution is indicated for radiolabeling OncoScint CR/OV or ProstaScint preparations used for in vivo diagnostic imaging procedures. It is also indicated for radiolabeling Zevalin preparations used for Radioimmunotherapy procedures. Please refer to the package insert for OncoScint CR/OV, ProstaScint or Zevalin for information on the final drug product. Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk. Indium In 111 ProstaScint is also indicated as a diagnostic imaging agent in post-prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation in whom there is a high clinical suspicion of occult metastatic disease. The imaging performance of Indium In 111 ProstaScint following radiation therapy has not been studied.

Launch Date

8.3626557E11
PubMed

PubMed

TitleDatePubMed
Preparation of indium-115-labeled diethylenetriaminetetraacetic acid monoacetamide peptides purified by 8-hydroxyquinoline.
2000 Dec 1
Patents

Sample Use Guides

Indium In 111 ProstaScint (Capromab Pendetide) has been administered in single doses to over 600 patients in clinical studies, and in repeat administrations (2 to 4 infusions) to 61 patients. A 0.5 mg dose was determined to be the lowest effective dose.
Route of Administration: Intravenous
One million alveolar macrophages obtained from hamsters were exposed to 60 ug of ferrosoferric oxide and 2, 4, 10 and 20 ug of Indium arsenide (InAs) particles.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:44:03 UTC 2023
Edited
by admin
on Fri Dec 15 19:44:03 UTC 2023
Record UNII
N0U96UKW4A
Record Status Validated (UNII)
Record Version
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Name Type Language
INDIUM SULFIDE
Systematic Name English
DIINDIUM TRISULFIDE
Common Name English
INDIUM SULFIDE (IN2S3)
Common Name English
Code System Code Type Description
PUBCHEM
160966
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
CAS
12030-24-9
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
FDA UNII
N0U96UKW4A
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
ECHA (EC/EINECS)
234-742-3
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
WIKIPEDIA
Indium sulfide
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
EPA CompTox
DTXSID20423030
Created by admin on Fri Dec 15 19:44:03 UTC 2023 , Edited by admin on Fri Dec 15 19:44:03 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE