TILAVONEMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 09:40:53 GMT 2023` Edited by `admin` on `Sat Dec 16 09:40:53 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	MY9Z7GDJ8J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TILAVONEMAB

Official Name

English

tilavonemab [INN]

Common Name

English

IMMUNOGLOBULIN G4, ANTI-(HUMAN TAU PROTEIN) (HUMAN-MUS MUSCULUS MONOCLONAL PR-1649264 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL PR-1649264 .KAPPA.-CHAIN, DIMER

Systematic Name

English

ABBV-8E12

Code

English

TILAVONEMAB [USAN]

Common Name

English

C2N8E12

Code

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS MAPT (MICROTUBULE-ASSOCIATED PROTEIN TAU, TAU)), MONOCLONAL ANTIBODYGAMMA4 HEAVY CHAIN (1-442) (VH (MUS MUSCULUS IGHV6-3*01 (91.9%)-(IGHD)-IGHJ4*01 (92.3%)/HOMO SAPIENS IGHV3-7*01 (71.4%)-(IGHD)-IGHJ4*01 (92.3%

Systematic Name

English

C2N-8E12

Code

English

Code System Code Type Description

USAN

HI-128

Created by admin on Sat Dec 16 09:40:53 GMT 2023 , Edited by admin on Sat Dec 16 09:40:53 GMT 2023

PRIMARY

INN

10957

Created by admin on Sat Dec 16 09:40:53 GMT 2023 , Edited by admin on Sat Dec 16 09:40:53 GMT 2023

PRIMARY

CAS

2096513-89-0

Created by admin on Sat Dec 16 09:40:53 GMT 2023 , Edited by admin on Sat Dec 16 09:40:53 GMT 2023

PRIMARY

FDA UNII

MY9Z7GDJ8J

Created by admin on Sat Dec 16 09:40:53 GMT 2023 , Edited by admin on Sat Dec 16 09:40:53 GMT 2023

PRIMARY

NCI_THESAURUS

C174727

Created by admin on Sat Dec 16 09:40:53 GMT 2023 , Edited by admin on Sat Dec 16 09:40:53 GMT 2023

PRIMARY

From	To
1_22	1_98
1_142	1_198
1_256	1_316
1_362	1_420
2_22	2_98
2_142	2_198
2_256	2_316
2_362	2_420
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_129	3_218
2_129	4_218
1_221	2_221
1_224	2_224

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_292
N	2_292

Related Record Type Details


					QR9EFE0TG6

MICROTUBULE-ASSOCIATED PROTEIN TAU (PAIRED HELICAL FILAMENTS (PHF))

TARGET->INHIBITOR OF AGGREGATION

Comments:

Recognizes an aggregated, extracellular form of pathological tau.

Amount:

Related Record Type Details


					MY9Z7GDJ8J

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL