Stereochemistry | ACHIRAL |
Molecular Formula | C7H4Cl3NO3 |
Molecular Weight | 256.471 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)COC1=NC(Cl)=C(Cl)C=C1Cl
InChI
InChIKey=REEQLXCGVXDJSQ-UHFFFAOYSA-N
InChI=1S/C7H4Cl3NO3/c8-3-1-4(9)7(11-6(3)10)14-2-5(12)13/h1H,2H2,(H,12,13)
Molecular Formula | C7H4Cl3NO3 |
Molecular Weight | 256.471 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Triclopyr is a chloropyridinyl compound herbicide used against woody and herbaceous weeds. Most triclopyr is sold as a triethylamine salt (abbreviated TEA) or butoxyethyl ester (abbreviated BEE) derivative of the parent chemical, triclopyr acid. Triclopyr TEA was registered with the EPA in 1979 and triclopyr BEE was registered in 1980 (#EPA). Both chemicals are used for weed control in forests, pastures, and on other grasses including home lawns.Triclopyr is sold under names such as Access, Crossbow, ET, Garlon, Grazon, PathFinder, Redeem, Rely, Remedy, and Turflon. It is often mixed other herbicides like picloram or 2,4-D to target a greater range of plant pests Triclopyr controls target weeds by mimicking the
plant hormone auxin, causing uncontrolled plant
growth. Low concentrations of triclopyr can stimulate RNA, DNA, and protein synthesis
leading to uncontrolled cell division and growth, and, ultimately, vascular tissue destruction.
Conversely, high concentrations of triclopyr can inhibit cell division and growth.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
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PubMed
Sample Use Guides
The oral LD50 of triclopyr in rats ranges from 630 to 729 mg/kg. Rats fed diets containing between 3 and 30 mg/kg/day of triclopyr experienced no ill effects. Males fed much higher doses (100 mg/kg) had decreased liver and body weight and increased kidney weight. The male mice were also sensitive at moderate doses. They had reduced liver weight at 60 mg/kg/day. Monkeys fed small amounts of triclopyr (30 mg/kg/day) had no adverse effects.
Route of Administration:
Oral