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Details

Stereochemistry ACHIRAL
Molecular Formula C7H4Cl3NO3
Molecular Weight 256.471
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICLOPYR

SMILES

OC(=O)COC1=NC(Cl)=C(Cl)C=C1Cl

InChI

InChIKey=REEQLXCGVXDJSQ-UHFFFAOYSA-N
InChI=1S/C7H4Cl3NO3/c8-3-1-4(9)7(11-6(3)10)14-2-5(12)13/h1H,2H2,(H,12,13)

HIDE SMILES / InChI

Molecular Formula C7H4Cl3NO3
Molecular Weight 256.471
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Triclopyr is a chloropyridinyl compound herbicide used against woody and herbaceous weeds. Most triclopyr is sold as a triethylamine salt (abbreviated TEA) or butoxyethyl ester (abbreviated BEE) derivative of the parent chemical, triclopyr acid. Triclopyr TEA was registered with the EPA in 1979 and triclopyr BEE was registered in 1980 (#EPA). Both chemicals are used for weed control in forests, pastures, and on other grasses including home lawns.Triclopyr is sold under names such as Access, Crossbow, ET, Garlon, Grazon, PathFinder, Redeem, Rely, Remedy, and Turflon. It is often mixed other herbicides like picloram or 2,4-D to target a greater range of plant pests Triclopyr controls target weeds by mimicking the plant hormone auxin, causing uncontrolled plant growth. Low concentrations of triclopyr can stimulate RNA, DNA, and protein synthesis leading to uncontrolled cell division and growth, and, ultimately, vascular tissue destruction. Conversely, high concentrations of triclopyr can inhibit cell division and growth.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
The oral LD50 of triclopyr in rats ranges from 630 to 729 mg/kg. Rats fed diets containing between 3 and 30 mg/kg/day of triclopyr experienced no ill effects. Males fed much higher doses (100 mg/kg) had decreased liver and body weight and increased kidney weight. The male mice were also sensitive at moderate doses. They had reduced liver weight at 60 mg/kg/day. Monkeys fed small amounts of triclopyr (30 mg/kg/day) had no adverse effects.
Route of Administration: Oral
In Vitro Use Guide
Triclopyr significantly reduced the radial growth of ectomycorrhizal fungi at concentrations >/= 1000 ppm. Growth was completely inhibited at concentrations >/= 5000 ppm.
Substance Class Chemical
Record UNII
MV06PHJ6I0
Record Status Validated (UNII)
Record Version