Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C33H41N5O6S2 |
| Molecular Weight | 667.839 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSC[C@H](NC(=O)COC1=C2C=CN=CC2=CC=C1)C(=O)N[C@@H](CC3=CC=CC=C3)[C@H](O)C(=O)N4CSC[C@H]4C(=O)NC(C)(C)C
InChI
InChIKey=NJBBLOIWMSYVCQ-VZTVMPNDSA-N
InChI=1S/C33H41N5O6S2/c1-33(2,3)37-31(42)26-19-46-20-38(26)32(43)29(40)24(15-21-9-6-5-7-10-21)36-30(41)25(18-45-4)35-28(39)17-44-27-12-8-11-22-16-34-14-13-23(22)27/h5-14,16,24-26,29,40H,15,17-20H2,1-4H3,(H,35,39)(H,36,41)(H,37,42)/t24-,25-,26-,29-/m0/s1
| Molecular Formula | C33H41N5O6S2 |
| Molecular Weight | 667.839 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties. | 2007-08-01 |
|
| Oxidative modifications of kynostatin-272, a potent human immunodeficiency virus type 1 protease inhibitor: potential mechanism for altered activity in monocytes/macrophages. | 2002-02 |
|
| Targets of a protease inhibitor, KNI-272, in HIV-1-infected cells. | 2001-03 |
|
| Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor. | 2001-02 |
|
| Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor. | 2000-09 |
|
| Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere. | 2000-09 |
|
| Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. | 1999-05-20 |
|
| A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor. | 1999-03-22 |
|
| Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. | 1998-08 |
|
| Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins. | 1998-04-23 |
|
| KNI-577, a potent small-sized HIV protease inhibitor based on the dipeptide containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic. | 1998-03 |
|
| HIV-1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure. | 1997-06 |
|
| Lecithinized superoxide dismutase: an inhibitor of human immunodeficiency virus replication. | 1997-03-01 |
|
| Assessment of a cytoprotection assay for the discovery and evaluation of anti-human immunodeficiency virus compounds utilizing a genetically-impaired virus. | 1996-04-26 |
|
| Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere. | 1996 |
|
| Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. | 1995-07-25 |
|
| A simple and rapid method for preliminary evaluation of in vivo efficacy of anti-HIV compounds in mice. | 1995-05 |
|
| Solubilization of a tripeptide HIV protease inhibitor using a combination of ionization and complexation with chemically modified cyclodextrins. | 1994-08 |
|
| Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins. | 1994-05 |
|
| In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine. | 1993-04 |
|
| Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine. | 1992-08 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:29:58 GMT 2025
by
admin
on
Mon Mar 31 18:29:58 GMT 2025
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| Record UNII |
MUL0OE3YBF
|
| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C783
Created by
admin on Mon Mar 31 18:29:58 GMT 2025 , Edited by admin on Mon Mar 31 18:29:58 GMT 2025
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| Code System | Code | Type | Description | ||
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60927
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147318-81-8
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MUL0OE3YBF
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PRIMARY | |||
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DTXSID90933095
Created by
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651714
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admin on Mon Mar 31 18:29:58 GMT 2025 , Edited by admin on Mon Mar 31 18:29:58 GMT 2025
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C29140
Created by
admin on Mon Mar 31 18:29:58 GMT 2025 , Edited by admin on Mon Mar 31 18:29:58 GMT 2025
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PRIMARY | NCIT |