Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H12N.Cl |
| Molecular Weight | 205.683 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2
InChI
InChIKey=LMGBDZJLZIPJPZ-UHFFFAOYSA-M
InChI=1S/C12H12N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H12N |
| Molecular Weight | 170.2304 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. | 2002-07 |
|
| Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. | 2002-07 |
|
| 1-Methyl-4-phenylpyridinium ion, a toxin that can cause parkinsonism, alters branched structures of DNA. | 2002-07 |
|
| cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. | 2002-07 |
|
| Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. | 2002-07 |
|
| Progressive alteration of neuronal dopamine transporter activity in a rat injured by an intranigral injection of MPP+. | 2002-06-21 |
|
| The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. | 2002-06-21 |
|
| Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. | 2002-06-15 |
|
| Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping. | 2002-06-14 |
|
| Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease. | 2002-06 |
|
| MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. | 2002-05-10 |
|
| Synthetic neuromelanin is toxic to dopaminergic cell cultures. | 2002-05 |
|
| Pergolide protects dopaminergic neurons in primary culture under stress conditions. | 2002-05 |
|
| Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP(+)) toxicity in vitro. | 2002-05 |
|
| Contradictory effects of sodium nitroprusside and S-nitroso-N-acetylpenicillamine on oxidative stress in brain dopamine neurons in vivo. | 2002-05 |
|
| Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. | 2002-05 |
|
| Regulation of [(3)H]MPP(+) transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase. | 2002-05 |
|
| Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway. | 2002-05 |
|
| Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms. | 2002-04-15 |
|
| Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. | 2002-04-01 |
|
| Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons. | 2002-04-01 |
|
| Capillary electrophoretic determination of apoptosis of rat cerebellar granule cells induced by 1-methyl-4-phenyl pyridium ion. | 2002-04 |
|
| Semicarbazide-sensitive amine oxidase (SSAO) in the brain. | 2002-04 |
|
| Amino acids involved in differences in the pharmacological profiles of the rat and human noradrenaline transporters. | 2002-04 |
|
| Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells. | 2002-04 |
|
| The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells. | 2002-03-22 |
|
| Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells. | 2002-03-15 |
|
| Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. | 2002-03 |
|
| Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells. | 2002-03 |
|
| Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. | 2002-02-15 |
|
| Protection of dopaminergic neurons in primary culture by lisuride. | 2002-02 |
|
| Differential expression of Bcl-2 and APP immunoreactivity after intrastriatal injection of MPP+ in the rat. | 2002-02 |
|
| Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture. | 2002-01 |
|
| Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease. | 2002-01 |
|
| Nitric oxide and depolarization induce hydroxyl radical generation. | 2002-01 |
|
| Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. | 2002-01 |
|
| Comparative study of the neuroprotective effect of dehydroepiandrosterone and 17beta-estradiol against 1-methyl-4-phenylpyridium toxicity on rat striatum. | 2002 |
|
| Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. | 2002 |
|
| Protective effect of histidine on para-nonylphenol-enhanced hydroxyl free radical generation induced by 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatum. | 2001-12-05 |
|
| Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. | 2001-12 |
|
| Protective effect and mechanism of Ginkgo biloba leaf extracts for Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | 2001-12 |
|
| Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment. | 2001-11-30 |
|
| [Human GDNF cDNA-engineered SH-SY5Y cells' neurotrophic and protective effect on primary dopaminergic neurons of rat]. | 2001-11-25 |
|
| Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. | 2001-11-16 |
|
| Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors. | 2001-11-13 |
|
| EGb761 blocks MPP+-induced lipid peroxidation in mouse corpus striatum. | 2001-11 |
|
| Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. | 2001-11 |
|
| Mechanisms of MPP(+) incorporation into cerebellar granule cells. | 2001-09-15 |
|
| Eldepryl prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral neuronal apoptosis in mice. | 2001-03 |
|
| Stimulation of the regrowth of MPP+-damaged dopaminergic fibers by the treatment of mesencephalic cultures with basigin. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:11:17 GMT 2025
by
admin
on
Mon Mar 31 20:11:17 GMT 2025
|
| Record UNII |
MRP3DNB9K9
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
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| Code System | Code | Type | Description | ||
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94497
Created by
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DTXSID8041826
Created by
admin on Mon Mar 31 20:11:17 GMT 2025 , Edited by admin on Mon Mar 31 20:11:17 GMT 2025
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cyperquat chloride
Created by
admin on Mon Mar 31 20:11:17 GMT 2025 , Edited by admin on Mon Mar 31 20:11:17 GMT 2025
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39794-99-5
Created by
admin on Mon Mar 31 20:11:17 GMT 2025 , Edited by admin on Mon Mar 31 20:11:17 GMT 2025
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MRP3DNB9K9
Created by
admin on Mon Mar 31 20:11:17 GMT 2025 , Edited by admin on Mon Mar 31 20:11:17 GMT 2025
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PARENT -> SALT/SOLVATE |
