EPINEPHRYL BORATE

First approved in 1961

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H12BNO4
Molecular Weight	209.007
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)C1=CC=C2OB(O)OC2=C1

InChI

InChIKey=ZNMXKJDERFMXNF-ZETCQYMHSA-N

InChI=1S/C9H12BNO4/c1-11-5-7(12)6-2-3-8-9(4-6)15-10(13)14-8/h2-4,7,11-13H,5H2,1H3/t7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C9H12BNO4
Molecular Weight	209.007
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.syrianclinic.com/med/en/ProfDrugs/EpinephrylBoratepd.html | https://www.drugs.com/cons/epinephryl-borate-ophthalmic.html

EPINEPHRYL BORATE (Epinal®) is an epinephrine derivative, which reduces elevated intraocular pressure in chronic open-angle glaucoma. It may also be used in eye surgery.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Open angle glaucoma 1 Sources: https://books.google.ru/books?id=Rppwm4GbcckC&pg=RA1-PA201&lpg=RA1-PA201&dq=EPINEPHRYL+BORATE retrieved from CRC Desk Reference of Clinical Pharmacology: Manuchair Ebadi, p. 202	Primary		Approved 8429	Epinal Approved Use Reduces elevated intraocular pressure in chronic open-angle glaucoma

Doses

Dose	Population	Adverse events
1 % single, ophthalmic Dose: 1 % Route: ophthalmic Route: single Dose: 1 % Sources: https://pubmed.ncbi.nlm.nih.gov/1200898/	healthy, adult n = 20 Health Status: healthy Condition: model of allergic conjunctivitis Age Group: adult Sex: unknown Population Size: 20 Sources: https://pubmed.ncbi.nlm.nih.gov/1200898/	Sources: https://pubmed.ncbi.nlm.nih.gov/1200898/

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	5579-16-8	https://www.alfa-chemistry.com/cas_5579-16-8.htm
BLD Pharm	BD47435	http://www.bldpharm.com/products/5579-16-8.html
Chemspace	CSC010593622
Chemspace	CSC037902342
Compound Cloud	10242182
Enamine	BBV-45411716
Enamine	BBV-77782671
Smolecule	S527277	http://www.smolecule.com/products/s527277
THE BioTek	bt-267479	https://www.thebiotek.com/product/inhibitors/bt-267479
ZINC	ZINC000169745622	http://zinc15.docking.org/substances/ZINC000169745622
eMolecules	260996096
eMolecules	266323868
eNovation Chemicals	K71569	https://www.enovationchem.com/ProductDetails.asp?ProductID=K71569
mcule	MCULE-6162779605

Sample Use Guides

In Vivo Use Guide

Instill 1 drop into the eyes once or twice daily.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:45 GMT 2023`
Record UNII	MO99IGH0LS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPINEPHRYL BORATE

Official Name

English

EPINEPHRYL BORATE [VANDF]

Common Name

English

Epinephryl borate [WHO-DD]

Common Name

English

(-)-3,4-DIHYDROXY-.ALPHA.-((METHYLAMINO)METHYL)BENZYL ALCOHOL, CYCLIC 3,4-ESTER WITH BORIC ACID

Common Name

English

1,3,2-BENZODIOXABOROLE-5-METHANOL, 2-HYDROXY-.ALPHA.-((METHYLAMINO)METHYL)-, (R)-

Systematic Name

English

EPINEPHRYL BORATE [USP IMPURITY]

Common Name

English

EPINEPHRYL BORATE [USAN]

Common Name

English

Code System Code Type Description

MESH

C018285