Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C\N=[N+](\C)[O-]
InChI
InChIKey=DGAKHGXRMXWHBX-ARJAWSKDSA-N
InChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3-
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Organ-specific carcinogenesis in rats by methyl- and ethylazoxyalkanes. | 1985 Jan |
|
| Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats. | 1986 Sep |
|
| Carcinogenesis by nitrosodialkylamines and azoxyalkanes given by gavage to rats and hamsters. | 1987 Aug 1 |
|
| Specificity study to evaluate induction of aberrant crypts in murine colons. | 1988 Nov 1 |
|
| Chemoprevention of colon carcinogenesis by organosulfur compounds. | 1993 Aug 1 |
|
| Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon. | 1995 Dec |
|
| Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. | 1995 Mar 15 |
|
| Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells. | 1995 Oct |
|
| Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. | 1999 Oct |
|
| Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane. | 2000 Dec |
|
| Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens. | 2000 Jun 15 |
|
| Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats. | 2002 May |
|
| Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. | 2002 Sep |
|
| Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. | 2003 Jul 1 |
|
| Vehicle and mode of administration effects on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to bromodichloromethane. | 2004 Jan 9 |
|
| Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. | 2005 Dec 11 |
|
| Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. | 2005 Feb 1 |
|
| Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. | 2005 May 16 |
|
| Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. | 2006 Jun |
|
| Development of normal human colon cell cultures to identify priority unregulated disinfection by-products with a carcinogenic potential. | 2007 |
|
| Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. | 2007 Apr 15 |
|
| Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. | 2007 Jan |
|
| Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis. | 2007 Nov |
|
| Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. | 2008 Apr |
|
| Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. | 2008 Jan |
|
| Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. | 2008 Jan |
|
| Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. | 2009 Feb 12 |
|
| Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. | 2009 Jan 27 |
|
| Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. | 2009 Sep 1 |
|
| Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice. | 2010 Aug 11 |
|
| Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. | 2010 Feb |
|
| Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice. | 2010 Jan 27 |
|
| Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. | 2010 Jan 27 |
|
| N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. | 2010 Jun |
|
| Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. | 2010 Jun |
|
| Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse. | 2010 Mar |
|
| Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. | 2010 Sep |
|
| Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. | 2011 Aug 15 |
|
| Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. | 2011 Jan |
|
| Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure. | 2011 Jun |
|
| Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. | 2011 Mar 23 |
|
| Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. | 2012 Apr 15 |
|
| Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. | 2012 Jul 1 |
|
| Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. | 2012 Oct |
|
| Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. | 2013 |
|
| Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. | 2014 Sep 15 |
|
| Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice. | 2015 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:24:08 UTC 2023
by
admin
on
Fri Dec 15 17:24:08 UTC 2023
|
| Record UNII |
MO0N1J0SEN
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C1916
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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D001397
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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MO0N1J0SEN
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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C294
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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AZOXYMETHANE
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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171779
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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DTXSID3020124
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY | |||
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25843-45-2
Created by
admin on Fri Dec 15 17:24:08 UTC 2023 , Edited by admin on Fri Dec 15 17:24:08 UTC 2023
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PRIMARY |