Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C\N=[N+](\C)[O-]
InChI
InChIKey=DGAKHGXRMXWHBX-ARJAWSKDSA-N
InChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3-
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Organ-specific carcinogenesis in rats by methyl- and ethylazoxyalkanes. | 1985 Jan |
|
| Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. | 1995 Mar 15 |
|
| Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells. | 1995 Oct |
|
| The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue. | 1998 Dec 25 |
|
| Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process. | 1999 Jul 15 |
|
| ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats. | 2000 Jan |
|
| Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens. | 2000 Jun 15 |
|
| Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane. | 2002 Nov |
|
| Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. | 2003 Jul 1 |
|
| Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. | 2005 May 16 |
|
| Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model. | 2007 |
|
| Development of normal human colon cell cultures to identify priority unregulated disinfection by-products with a carcinogenic potential. | 2007 |
|
| Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. | 2007 Apr 15 |
|
| Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis. | 2007 Nov |
|
| Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. | 2008 Aug 15 |
|
| Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. | 2008 Jul |
|
| Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. | 2009 Feb 12 |
|
| Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. | 2009 Jan |
|
| Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. | 2009 Jan 27 |
|
| Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. | 2010 Jan 27 |
|
| Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. | 2010 Sep |
|
| Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. | 2011 Jan |
|
| Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2. | 2012 Apr |
|
| Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. | 2012 Oct |
|
| Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. | 2013 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:24:08 GMT 2023
by
admin
on
Fri Dec 15 17:24:08 GMT 2023
|
| Record UNII |
MO0N1J0SEN
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Systematic Name | English | ||
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Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C1916
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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D001397
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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PRIMARY | |||
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MO0N1J0SEN
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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C294
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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PRIMARY | |||
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AZOXYMETHANE
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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PRIMARY | |||
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171779
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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PRIMARY | |||
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DTXSID3020124
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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25843-45-2
Created by
admin on Fri Dec 15 17:24:08 GMT 2023 , Edited by admin on Fri Dec 15 17:24:08 GMT 2023
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PRIMARY |