Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C\N=[N+](\C)[O-]
InChI
InChIKey=DGAKHGXRMXWHBX-ARJAWSKDSA-N
InChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3-
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice. | 2015-01 |
|
| Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. | 2014-09-15 |
|
| Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. | 2013-12 |
|
| Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. | 2013 |
|
| Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. | 2012-10 |
|
| Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. | 2012-07-01 |
|
| Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. | 2012-04-15 |
|
| Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2. | 2012-04 |
|
| Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway. | 2012 |
|
| Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. | 2011-08-15 |
|
| Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure. | 2011-06 |
|
| Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. | 2011-03-23 |
|
| Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. | 2011-01 |
|
| Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. | 2010-09 |
|
| Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice. | 2010-08-11 |
|
| N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. | 2010-06 |
|
| Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. | 2010-06 |
|
| Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse. | 2010-03 |
|
| Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. | 2010-02 |
|
| Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice. | 2010-01-27 |
|
| Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. | 2010-01-27 |
|
| Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. | 2009-09-01 |
|
| Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. | 2009-02-12 |
|
| Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. | 2009-01-27 |
|
| Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. | 2009-01 |
|
| Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. | 2008-08-15 |
|
| Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. | 2008-07 |
|
| Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. | 2008-04 |
|
| Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. | 2008-01 |
|
| Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. | 2008-01 |
|
| Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. | 2008 |
|
| Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis. | 2007-11 |
|
| Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. | 2007-04-15 |
|
| Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. | 2007-01 |
|
| Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model. | 2007 |
|
| Development of normal human colon cell cultures to identify priority unregulated disinfection by-products with a carcinogenic potential. | 2007 |
|
| Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. | 2006-06 |
|
| Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. | 2005-12-11 |
|
| Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. | 2005-05-16 |
|
| Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. | 2005-03 |
|
| Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. | 2005-02-01 |
|
| Vehicle and mode of administration effects on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to bromodichloromethane. | 2004-01-09 |
|
| Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon. | 1995-12 |
|
| Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells. | 1995-10 |
|
| Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. | 1995-03-15 |
|
| Chemoprevention of colon carcinogenesis by organosulfur compounds. | 1993-08-01 |
|
| Specificity study to evaluate induction of aberrant crypts in murine colons. | 1988-11-01 |
|
| Carcinogenesis by nitrosodialkylamines and azoxyalkanes given by gavage to rats and hamsters. | 1987-08-01 |
|
| Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats. | 1986-09 |
|
| Organ-specific carcinogenesis in rats by methyl- and ethylazoxyalkanes. | 1985-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:45:41 GMT 2025
by
admin
on
Mon Mar 31 18:45:41 GMT 2025
|
| Record UNII |
MO0N1J0SEN
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Systematic Name | English | ||
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Preferred Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C1916
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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D001397
Created by
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PRIMARY | |||
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300000053072
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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MO0N1J0SEN
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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C294
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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PRIMARY | |||
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AZOXYMETHANE
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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171779
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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DTXSID3020124
Created by
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25843-45-2
Created by
admin on Mon Mar 31 18:45:41 GMT 2025 , Edited by admin on Mon Mar 31 18:45:41 GMT 2025
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PRIMARY |