Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H29NO2.BrH |
| Molecular Weight | 420.383 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.CN1[C@@H](C[C@@H](O)C2=CC=CC=C2)CCC[C@H]1C[C@H](O)C3=CC=CC=C3
InChI
InChIKey=MTGGITMQSKBNME-NRDKKTCLSA-N
InChI=1S/C22H29NO2.BrH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-22,24-25H,8,13-16H2,1H3;1H/t19-,20+,21-,22+;
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C22H29NO2 |
| Molecular Weight | 339.4712 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19217305 | https://www.ncbi.nlm.nih.gov/pubmed/17658751
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19217305 | https://www.ncbi.nlm.nih.gov/pubmed/17658751
Lobelanidine is one of lobelia alkaloids that are the constituents of Lobelia inflata. Lobelia Chinensis Lour. (L. chinensis) is a plant of the Campanulaceae family that is commonly known as "xi-mi-cao", and "she-she-cao". It has been widely used as an antidote, diuretic, and hemostat in traditional Chinese medicine for decades. Lobelanidine is known for its emetic and anticancer activity.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36544 Gene ID: 1139|||89832 Gene Symbol: CHRNA7 Target Organism: Homo sapiens (Human) |
|||
Target ID: CHEMBL1907594 |
300.0 nM [Ki] | ||
Target ID: CHEMBL1907594 |
|||
Target ID: CHEMBL321 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:06:11 GMT 2023
by
admin
on
Sat Dec 16 10:06:11 GMT 2023
|
| Record UNII |
MNQ83B2861
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
m280
Created by
admin on Sat Dec 16 10:06:11 GMT 2023 , Edited by admin on Sat Dec 16 10:06:11 GMT 2023
|
PRIMARY | Merck Index | ||
|
90478427
Created by
admin on Sat Dec 16 10:06:11 GMT 2023 , Edited by admin on Sat Dec 16 10:06:11 GMT 2023
|
PRIMARY | |||
|
6112-87-4
Created by
admin on Sat Dec 16 10:06:11 GMT 2023 , Edited by admin on Sat Dec 16 10:06:11 GMT 2023
|
PRIMARY | |||
|
MNQ83B2861
Created by
admin on Sat Dec 16 10:06:11 GMT 2023 , Edited by admin on Sat Dec 16 10:06:11 GMT 2023
|
PRIMARY |