Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H16BNO4.ClH |
| Molecular Weight | 273.521 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC[C@H]1OB(O)C2=C1C=CC=C2OCCCO
InChI
InChIKey=DADYQGIQOBJGIW-HNCPQSOCSA-N
InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10;/h1,3-4,10,14-15H,2,5-7,13H2;1H/t10-;/m1./s1
| Molecular Formula | C11H16BNO4 |
| Molecular Weight | 237.06 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Epetraborole (AN3365 or GSK2251052) is a novel boron-containing antibiotic that inhibits bacterial leucyl tRNA synthetase. It is active against Gram-negative bacteria, including Enterobacteriaceae bearing NDM-1 and KPC carbapenemases, as well as P. aeruginosa. Epetraborole was under development for the treatment of Gram-negative bacterial infections.
Originator
Approval Year
Sample Use Guides
Epetraborole (AN3365 or GSK2251052) (MIC(50/90), 0.5/1 μg/ml) was active against Enterobacteriaceae, including a subset of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains (MIC(50/90), 1/2 μg/ml). AN3365 inhibited 98.0 and 92.2% of wild-type (MIC(50/90), 2/8 μg/ml) and carbapenem-resistant (MIC(50/90), 4/8 μg/ml) Pseudomonas aeruginosa strains, respectively, at ≤ 8 μg/ml. AN3365 also demonstrated activity against wild-type Acinetobacter baumannii (MIC(50/90), 2/8 μg/ml) and Stenotrophomonas maltophilia (MIC(50/90), 2/4 μg/ml), while it was less active against multidrug-resistant A. baumannii (MIC50/90, 8/16 μg/ml) and Burkholderia cepacia (MIC(50/90), 8/32 μg/ml).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:19:41 GMT 2023
by
admin
on
Sat Dec 16 01:19:41 GMT 2023
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| Record UNII |
MM0NZY12FA
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| Record Status |
Validated (UNII)
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| Record Version |
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FDA ORPHAN DRUG |
860621
Created by
admin on Sat Dec 16 01:19:42 GMT 2023 , Edited by admin on Sat Dec 16 01:19:42 GMT 2023
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| Code System | Code | Type | Description | ||
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1234563-16-6
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DBSALT002062
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52918389
Created by
admin on Sat Dec 16 01:19:42 GMT 2023 , Edited by admin on Sat Dec 16 01:19:42 GMT 2023
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MM0NZY12FA
Created by
admin on Sat Dec 16 01:19:42 GMT 2023 , Edited by admin on Sat Dec 16 01:19:42 GMT 2023
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PRIMARY |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |