MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:19:56 GMT 2025` Edited by `admin` on `Wed Apr 02 04:19:56 GMT 2025`
Protein Type	ENZYME-REGULATOR PROTEIN COMPLEX
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	INCOMPLETE
Record UNII	MIF1PZF1OC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2

Common Name

English

MTORC2

Preferred Name

English

MTORC2 (CONTAINS MTOR, MLST8, PRR5, RICTOR, MAPKAP1 AND DEPTOR)

Common Name

English

Code System Code Type Description

UNIPROT

Q8TB45

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

UNIPROT

Q9BPZ7

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

UNIPROT

Q6R327

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

UNIPROT

Q9BVC4

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

UNIPROT

P42345

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

PRIMARY

UNIPROT

Q9BPZ7

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

UNIPROT

P85299

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

FDA UNII

MIF1PZF1OC

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

PRIMARY

UNIPROT

Q6MZQ0

Created by admin on Wed Apr 02 04:19:56 GMT 2025 , Edited by admin on Wed Apr 02 04:19:56 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

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					1C854K1MIJ

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INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [6_1]	SITE_SPECIFIC			N-ACETYLMETHIONINE	9J12WX5B6A
AMINO_ACID_SUBSTITUTION	[5_1] [8_1]	SITE_SPECIFIC			N-ACETYLALANINE	26C4VY6Z0M
AMINO_ACID_SUBSTITUTION	[1_1261] [1_2159] [1_2481] [3_252] [4_1235] [6_280] [7_28]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_2164] [1_2173]	SITE_SPECIFIC			THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL