Ibentatug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:08:15 GMT 2025` Edited by `admin` on `Wed Apr 02 13:08:15 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	other
Record UNII	MGW2V5VJ5J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ibentatug

Official Name

English

ZB-131

Preferred Name

English

ibentatug [INN]

Common Name

English

Immunoglobulin G1 [de-452-lysine], anti-(human plectin) (human-Mus musculus monoclonal ZB131 ?1-chain), disulfide with human-Mus musculus monoclonal ZB131 ?-chain, dimer

Common Name

English

Gamma1 heavy chain (1-451) [VH Musmus/Homsap (Mus musculus IGHV5-9-3*01 (87.8%) -(IGHD) -IGHJ3*01 (91.7%) A128>S (122)/Homo sapiens IGHV3-23*04 (86.7%) -(IGHD)-IGHJ4*01 (92.9%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01 (100%

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens CSP1 (cell surface plectin 1)], monoclonal antibody

Common Name

English

Ibentatug [WHO-DD]

Common Name

English

ZB131

Code

English

Code System Code Type Description

NCI_THESAURUS

C185127

Created by admin on Wed Apr 02 13:08:15 GMT 2025 , Edited by admin on Wed Apr 02 13:08:15 GMT 2025

PRIMARY

INN

12688

Created by admin on Wed Apr 02 13:08:15 GMT 2025 , Edited by admin on Wed Apr 02 13:08:15 GMT 2025

PRIMARY

SMS_ID

300000051885

Created by admin on Wed Apr 02 13:08:15 GMT 2025 , Edited by admin on Wed Apr 02 13:08:15 GMT 2025

PRIMARY

FDA UNII

MGW2V5VJ5J

Created by admin on Wed Apr 02 13:08:15 GMT 2025 , Edited by admin on Wed Apr 02 13:08:15 GMT 2025

PRIMARY

CAS

2767983-94-6

Created by admin on Wed Apr 02 13:08:15 GMT 2025 , Edited by admin on Wed Apr 02 13:08:15 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_149	2_205
2_225	4_219
2_266	2_326
1_149	1_205
2_372	2_430
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_225	3_219
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					MGW2V5VJ5J

Ibentatug

ACTIVE MOIETY

Comments:

ZB131 is a humanized IgG1 monoclonal antibody (mAb) directed against cancer-specific plectin (CSP) that is being developed for the treatment of patients with advanced (solid tumor) cancer.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL