Details
Stereochemistry | ACHIRAL |
Molecular Formula | C38H42N8O6S2 |
Molecular Weight | 770.92 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C\C(N(CC1=CN=C(C)N=C1N)C=O)=C(\CCOC(=O)C2=CC=CC=C2)SS\C(CCOC(=O)C3=CC=CC=C3)=C(/C)N(CC4=C(N)N=C(C)N=C4)C=O
InChI
InChIKey=IWXAZSAGYJHXPX-BCEWYCLDSA-N
InChI=1S/C38H42N8O6S2/c1-25(45(23-47)21-31-19-41-27(3)43-35(31)39)33(15-17-51-37(49)29-11-7-5-8-12-29)53-54-34(16-18-52-38(50)30-13-9-6-10-14-30)26(2)46(24-48)22-32-20-42-28(4)44-36(32)40/h5-14,19-20,23-24H,15-18,21-22H2,1-4H3,(H2,39,41,43)(H2,40,42,44)/b33-25+,34-26+
Molecular Formula | C38H42N8O6S2 |
Molecular Weight | 770.92 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
DescriptionSources: http://aksci.com/item_detail.php?cat=U842Curator's Comment: description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/14033912
http://www.ncbi.nlm.nih.gov/pubmed/14020786
Sources: http://aksci.com/item_detail.php?cat=U842
Curator's Comment: description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/14033912
http://www.ncbi.nlm.nih.gov/pubmed/14020786
Bisbentiamine is an O-benzoyl thiamine disulfide or vitamin B1 disulfide derivative. Thiamine derivatives and thiamine-dependent enzymes are present in all cells of the body, thus a thiamine deficiency would seem to adversely affect all of the organ systems. Lipid-soluble thiamine precursors such as Bisbentiamine have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. It is also used as a dietary supplement.
Originator
Approval Year
Sample Use Guides
The recommended adult daily dose is 1-4 tablets (25-100 mg) given orally.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/?term=14020786
1 ug of Bisbentiamine (BTDS) was incubated with L. ferinenti 36 and L. viridescens S38A for 24 hours at 37 C to measure the growth of these microorganisms.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:02:43 GMT 2023
by
admin
on
Fri Dec 15 16:02:43 GMT 2023
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Record UNII |
MEI78CAM16
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C45812
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3034022
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C037583
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m1028
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C81630
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1469
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Related Record | Type | Details | ||
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ACTIVE MOIETY |