Roconkibart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:36:28 GMT 2025` Edited by `admin` on `Wed Apr 02 18:36:28 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	MD885NVL3Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Roconkibart

Official Name

English

JS-005

Preferred Name

English

JS005

Code

English

gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV1-2*02(85.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (118-215), hinge 1-12 S10>P (225) (216-227),CH2 L92 (306) (22

Common Name

English

Immunoglobulin G4 [225-proline], anti-(human interleukin 17A) (human-Mus musculus monoclonal JS005 ?4-chain), disulfide with human-Mus musculus monoclonal JS005 ?-chain, dimer

Common Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A)], monoclonal antibody

Common Name

English

roconkibart [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203102

Created by admin on Wed Apr 02 18:36:28 GMT 2025 , Edited by admin on Wed Apr 02 18:36:28 GMT 2025

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SMS_ID

300000051887

Created by admin on Wed Apr 02 18:36:28 GMT 2025 , Edited by admin on Wed Apr 02 18:36:28 GMT 2025

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CAS

2638480-59-6

Created by admin on Wed Apr 02 18:36:28 GMT 2025 , Edited by admin on Wed Apr 02 18:36:28 GMT 2025

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FDA UNII

MD885NVL3Q

Created by admin on Wed Apr 02 18:36:28 GMT 2025 , Edited by admin on Wed Apr 02 18:36:28 GMT 2025

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INN

12736

Created by admin on Wed Apr 02 18:36:28 GMT 2025 , Edited by admin on Wed Apr 02 18:36:28 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_131	4_219
2_144	2_200
2_258	2_318
1_131	3_219
2_364	2_422
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_144	1_200
1_223	2_223
1_226	2_226
1_258	1_318
1_364	1_422

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_294
N	2_294

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET->LIGAND

Amount:

Related Record Type Details


					MD885NVL3Q

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_444] [2_444]		K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL