QUININE UREA HYDROCHLORIDE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O2.CH4N2O.ClH
Molecular Weight	420.933
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC(N)=O.COC1=CC=C2N=CC=C([C@@H](O)[C@@H]3C[C@@H]4CC[N@]3C[C@@H]4C=C)C2=C1

InChI

InChIKey=VSBIHZIPRXLKFY-HZQSTTLBSA-N

InChI=1S/C20H24N2O2.CH4N2O.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;2-1(3)4;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H4,2,3,4);1H/t13-,14-,19-,20+;;/m0../s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O2
Molecular Weight	324.4168
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4N2O
Molecular Weight	60.0553
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2583670 | https://www.ncbi.nlm.nih.gov/pubmed/14487920 | https://www.ncbi.nlm.nih.gov/pubmed/29008653

Quinine urea mixture is a long-acting local anesthetic and analgesic. However, the quinine-urea mixture could delay wound healing if directly injected into wound edges. A syringe with a long offset needle such as Moynihan’s for infiltrating “at a Distance from the Incision.” is recommended for quinine urea delivery.

Approval Year

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-064580	http://www.3bsc.com/index/pro_info.php?id=103771
Alfa Chemistry	549-52-0	https://www.alfa-chemistry.com/cas_549-52-0.htm
ChemMol	99104162	http://www.chemmol.com/chemmol/99104162.html
PubChem	56841939	https://pubchem.ncbi.nlm.nih.gov/compound/56841939

PubMed

Title	Date	PubMed
[Local anesthetic effect of quinine-urea].	1961	14487920
Quinine Urea Hydrochloride.	1918-06	29008653

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:00:23 GMT 2025` Edited by `admin` on `Mon Mar 31 18:00:23 GMT 2025`
Record UNII	MC4F54ADXA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUININE UREA HYDROCHLORIDE

Common Name

English

CINCHONAN-9-OL, 6'-METHOXY-, (8.ALPHA.,9R)-, COMPD. WITH UREA (1:1), DIHYDROCHLORIDE

Preferred Name

English

QUININE AND UREA HYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 310.547