METHALLIBURE

Details

Stereochemistry	RACEMIC
Molecular Formula	C7H14N4S2
Molecular Weight	218.343
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=S)NNC(=S)NC(C)C=C

InChI

InChIKey=CGFFKDRVHZIQHL-UHFFFAOYSA-N

InChI=1S/C7H14N4S2/c1-4-5(2)9-7(13)11-10-6(12)8-3/h4-5H,1H2,2-3H3,(H2,8,10,12)(H2,9,11,13)

HIDE SMILES / InChI

Molecular Formula	C7H14N4S2
Molecular Weight	218.343
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://link.springer.com/article/10.1023/A:1007707604097 | https://www.ncbi.nlm.nih.gov/pubmed/5435218 | https://www.ncbi.nlm.nih.gov/pubmed/6068966 | https://books.google.me/books?id=JfA4oF1s-xYC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Methallibure is a non-steroidal gonadotropin antagonist. It affects monoamine metabolism. Methallibure suppresses pituitary, ovarian and renal function. Methallibure has been used in veterinary to control estrus synchronization.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Estrus synchronization of gilts and sows by the oral administration of methallibure (I.C.I. compound 33828).	1967 May	6068966
Anti-gestation and teratogenic effects of Aimax (methallibure) in gilts.	1970 Feb	5435218
Identification of teleost gonadotrope cells using methallibure (ICI 33, 828) and thiourea.	1971 Feb 15	5549262
[Synchronization of estrus by the use of TURISYNCHRON-premix and insemination time in young gilts].	1974	4464816
Inhibition of thyroid function and thyrotrophic activity following the administration of methallibure (ICI-33 828).	1975 Feb	51791

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:02:55 GMT 2023` Edited by `admin` on `Fri Dec 15 19:02:55 GMT 2023`
Record UNII	MBU5XJ97C4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHALLIBURE

Official Name

English

AY 61122

Code

English

ICI 33,828

Code

English

ICI-33,828

Code

English

METALLIBURE [MART.]

Common Name

English

metallibure [INN]

Common Name

English

NSC-69536

Code

English

ICI-33828

Code

English

ICI 33828

Code

English

1,2-HYDRAZINEDICARBOTHIOAMIDE, N-METHYL-N'-(1-METHYL-2-PROPENYL)-

Systematic Name

English

1-Methyl-6-(1-methylallyl)-2,5-dithiobiurea

Systematic Name

English

METHALLIBURE [USAN]

Common Name

English

AY-61122

Code

English

METHALLIBURE [MI]

Common Name

English

METALLIBURE

Official Name

English

Code System Code Type Description

MERCK INDEX

m7288