Dicyandiamide

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H4N4
Molecular Weight	84.08
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NC#N

InChI

InChIKey=QGBSISYHAICWAH-UHFFFAOYSA-N

InChI=1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)

HIDE SMILES / InChI

Molecular Formula	C2H4N4
Molecular Weight	84.08
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26902689

Dicyandiamide is a nitrification inhibitor, used in agriculture. Its use may cause contamination of food.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Determination of impurities in medical products containing metformin hydrochloride.	2011-01-15	21229873
Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.	2010-12-12	21144000
Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index.	2010-02-02	20161987
Partial purification and characterization of the mode of action of enterocin S37: a bacteriocin produced by Enterococcus faecalis S37 isolated from poultry feces.	2010	20811593
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.	2009-10-22	19791743
Bis(1-carbamimidoyl-2-ethyl-isourea)copper(II) dinitrate.	2009-10-17	21578134
Development and validation of an analytical method for metformin hydrochloride and its related compound (1-cyanoguanidine) in tablet formulations by HPLC-UV.	2009-10-15	19635372
Different routes for amination of platinum(II)-bound cyanoguanidine.	2009-09-21	19689126
Bis(1-carbamimidoyl-2-ethyl-isourea)copper(II) bis-(perchlorate).	2009-09-05	21577707
Modulatory action of potassium channel openers on field potential and histamine release from rat peritoneal mast cells.	2009-08	19767887
Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug.	2009-06-29	19563661
Bis[diamino-(ethoxy-carbonyl-amino)-methyl-ium] sulfate.	2009-03-19	21582510
Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments.	2009-03-12	19284605
Selective P2X(7) receptor antagonists for chronic inflammation and pain.	2009-03	18568426
The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes.	2009-02	19136734
Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.	2007-11-29	17973362
Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.	2007-08-09	17630727
Novel P2X7 receptor antagonists ease the pain.	2007-07	17471176
Molecular structure, bioavailability and bioactivity of [Cu(o-phen)2(cnge)](NO3)2.2H2O and [Cu(o-phen)(cnge)(H2O)(NO3)2] complexes.	2007-05	17331582
Biodegradability of end-groups of the biocide polyhexamethylene biguanide (PHMB) assessed using model compounds.	2006-08	16683128
Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits.	2005-12-02	16319050
Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.	2005-08-22	16012520
Quantitative structure-activity relationship by CoMFA for cyclic urea and nonpeptide-cyclic cyanoguanidine derivatives on wild type and mutant HIV-1 protease.	2005-03	15714296
Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice.	2005	16508338
Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.	2004-12	15561900
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.	2004-06-03	15163199
Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes.	2004-06	15215643
Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828.	2004-05	15141009
Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.	2004-04	15023854
Design, synthesis, and biological evaluation of thio-containing compounds with serum HDL-cholesterol-elevating properties.	2004-01-29	14736248
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements.	2004-01-15	14723969
Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.	2004-01	15090743
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine.	2003-07-03	12825954
Bis(cyanoguanidine)silver(I) nitrate-cyanoguanidine (1/1).	2003-06	12794335
Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.	2003-03-20	12614878
Activation of p53 protein in normal and in tumor cells by a novel anticancer agent CHS 828.	2003	12951835
The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels.	2002-10-25	12171936
The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis.	2002-10	12359640
Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.	2002-09-26	12238930
Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitution.	2002-09-02	12161144
A Phase I study of CHS 828 in patients with solid tumor malignancy.	2002-09	12231525
Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients.	2002-09	12218267
Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.	2002-04-15	11996891
Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.	2002-02-25	11844681
A novel anti-ischemic ATP-sensitive potassium channel (K(ATP)) opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N' '-cyanoguanidine analogue.	2001-11-22	11708922
Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.	2001-02-12	11212115
A hollow fiber model for in vitro studies of cytotoxic compounds: activity of the cyanoguanidine CHS 828.	2001-01	11272284
Occupational allergic contact dermatitis caused by 2,4,6-tris-(dimethylaminomethyl)phenol, and review of sensitizing epoxy resin hardeners.	1996-12	8970840

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:40:02 GMT 2025` Edited by `admin` on `Mon Mar 31 21:40:02 GMT 2025`
Record UNII	M9B1R0C16H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Dicyandiamide

Common Name

English

METFORMIN RELATED COMPOUND A

Preferred Name

English

J3.635H

Code

English

CYANOGUANIDINE [HSDB]

Common Name

English

NSC-2031

Code

English

1-CYANOGUANIDINE

Systematic Name

English

CYANOGUANIDINE

Systematic Name

English

METFORMIN RELATED COMPOUND A [USP-RS]

Common Name

English

METFORMIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

METFORMIN RELATED COMPOUND A [USP IMPURITY]

Common Name

English

DICYANODIAMIDE [MI]

Common Name

English

N-CYANOGUANIDINE

Systematic Name

English

DCD

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 176.170