Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.3044 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OCCC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=ILRCGYURZSFMEG-RKQHYHRCSA-N
InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.3044 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Salidroside (Rhodioloside) is a glucoside which was isolated in 1926 from Salix triandra L. (Salicaceae). It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant, along with rosavin. Also was investigated that salidroside may be a promising candidate for the treatment of inflammatory liver injury and promotes skeletal regeneration in cell-autonomous and cell-non-autonomous ways and might be a potential therapy for accelerating fracture healing.
CNS Activity
Sources: doi/10.1111/jnc.13225/pdf Retrived from | http://onlinelibrary.wiley.com/doi/10.1111/jnc.13225/pdf
Curator's Comment: Known to be CNS penetrant in mouse, rat. Human data not available
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. | 2001 Apr |
|
| Separation of salidroside from Rhodiola crenulata by high-speed counter-current chromatography. | 2002 Sep 20 |
|
| Phenylpropanoid glycosides from Rhodiola rosea. | 2003 Apr |
|
| Benzoxazinoids and iridoid glucosides from four Lamium species. | 2003 Dec |
|
| High yield production of salidroside in the suspension culture of Rhodiola sachalinensis. | 2003 Dec 5 |
|
| Formation of benzoquinol moiety in cornoside by salidroside mono-oxygenase, a cytochrome P450 enzyme, from Abeliophyllum distichumcell suspension cultures. | 2003 Jan |
|
| Determination of p-tyrosol and salidroside in three samples of Rhodiola crenulata and one of Rhodiola kirilowii by capillary zone electrophoresis. | 2003 Sep |
|
| HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations. | 2005 Nov-Dec |
|
| Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. | 2005 Oct |
|
| [Effects of salidroside on bone marrow matrix metalloproteinases of bone marrow depressed anemic mice]. | 2006 Dec |
|
| [Determination of salidroside and p-tyrosol in Hongjingtian for injection(freezing-dry) by SPE-HPLC]. | 2006 Jan |
|
| [Study on the extraction process for salidroside and p-tyrosol in Rhodiola crenulata]. | 2006 Nov |
|
| Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. | 2007 Jan |
|
| Salidroside production by hairy roots of Rhodiola sachalinensis obtained after transformation with Agrobacterium rhizogenes. | 2007 Mar |
|
| Simultaneous determination of salidroside and tyrosol in extracts of Rhodiola L. by microwave assisted extraction and high-performance liquid chromatography. | 2007 Nov 5 |
|
| Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease. | 2007 Oct |
|
| Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinensis. | 2007 Sep |
|
| [Phenolic components from herbs of Dendrobium aphyllum]. | 2008 Dec |
|
| Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. | 2009 Apr 1 |
|
| Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. | 2009 Aug |
|
| Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. | 2009 Jun 24 |
|
| The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. | 2009 Mar |
|
| Phenolic compounds in ectomycorrhizal interaction of lignin modified silver birch. | 2009 Sep 29 |
|
| Protective role of salidroside against aging in a mouse model induced by D-galactose. | 2010 Apr |
|
| Synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis. | 2010 Aug |
|
| Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity. | 2010 Jan |
|
| Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. | 2010 Jul 16 |
|
| Short communication: Influence of pasteurization on the active compounds in medicinal plants to be used in dairy products. | 2010 Jun |
|
| Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. | 2010 Nov |
Sample Use Guides
in mice: C57BL/6 mice were orally administrated salidrosid for continuous 5 days, followed by three gavages of ethanol every 30 min
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: Pretreatment of the human umbilical vein endothelial cells (HUVECs) with Salidroside (SAL) significantly reduced the cell damage effects brought by homocysteine (Hcy) in a dose-dependent manner. Functional studies on the HUVECs found that SAL rescued the endoplasmic reticulum stress induced by Hcy. The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1α).
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:45:03 GMT 2023
by
admin
on
Sat Dec 16 08:45:03 GMT 2023
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| Record UNII |
M983H6N1S9
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| Record Status |
Validated (UNII)
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| Record Version |
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M983H6N1S9
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Rhodioloside
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159278
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