Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.3044 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OCCC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=ILRCGYURZSFMEG-RKQHYHRCSA-N
InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.3044 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Salidroside (Rhodioloside) is a glucoside which was isolated in 1926 from Salix triandra L. (Salicaceae). It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant, along with rosavin. Also was investigated that salidroside may be a promising candidate for the treatment of inflammatory liver injury and promotes skeletal regeneration in cell-autonomous and cell-non-autonomous ways and might be a potential therapy for accelerating fracture healing.
CNS Activity
Sources: doi/10.1111/jnc.13225/pdf Retrived from | http://onlinelibrary.wiley.com/doi/10.1111/jnc.13225/pdf
Curator's Comment: Known to be CNS penetrant in mouse, rat. Human data not available
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. | 2010-12 |
|
| Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. | 2010-11 |
|
| Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. | 2010-09-13 |
|
| Synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis. | 2010-08 |
|
| Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. | 2010-07-16 |
|
| Short communication: Influence of pasteurization on the active compounds in medicinal plants to be used in dairy products. | 2010-06 |
|
| In-vitro promoted differentiation of mesenchymal stem cells towards hepatocytes induced by salidroside. | 2010-04 |
|
| Protective role of salidroside against aging in a mouse model induced by D-galactose. | 2010-04 |
|
| Evaluation of salidroside in vitro and in vivo genotoxicity. | 2010-04 |
|
| Biosynthesis of acteoside in cultured cells of Olea europaea. | 2010-04 |
|
| Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. | 2010-03 |
|
| [Effects of salidroside on tubular epithelial to myofibroblast transition under cobaltous chloride induced hypoxic status]. | 2010-01 |
|
| Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity. | 2010-01 |
|
| Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis. | 2009-12 |
|
| Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. | 2009-12 |
|
| Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. | 2009-10-31 |
|
| Hepatoprotective effects of salidroside on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. | 2009-10 |
|
| Phenolic compounds in ectomycorrhizal interaction of lignin modified silver birch. | 2009-09-29 |
|
| Isolation and genotype-dependent, organ-specific expression analysis of a Rhodiola rosea cDNA encoding tyrosine decarboxylase. | 2009-09-15 |
|
| Salidroside, the main active compound of Rhodiola plants, inhibits high glucose-induced mesangial cell proliferation. | 2009-09 |
|
| Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. | 2009-08 |
|
| Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride. | 2009-08 |
|
| Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. | 2009-06-24 |
|
| Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. | 2009-06-22 |
|
| Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. | 2009-06 |
|
| Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. | 2009-05 |
|
| HPLC analysis, semi-preparative HPLC preparation and identification of three impurities in salidroside bulk drug. | 2009-04-05 |
|
| Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. | 2009-04-01 |
|
| [Salidroside protects the hypothalamic-pituitary-gonad axis of male rats undergoing negative psychological stress in experimental navigation and intensive exercise]. | 2009-04 |
|
| [Protective effects of salidroside on oxidative damage in fatigue mice]. | 2009-03 |
|
| The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. | 2009-03 |
|
| Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. | 2009-03 |
|
| [Effects of salidroside-pretreatment on neuroethology of rats after global cerebral ischemia-reperfusion]. | 2009-02 |
|
| Preparative purification of salidroside from Rhodiola rosea by two-step adsorption chromatography on resins. | 2009-01 |
|
| [Phenolic components from herbs of Dendrobium aphyllum]. | 2008-12 |
|
| Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. | 2008-12 |
|
| Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. | 2008-10-31 |
|
| Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. | 2008-09 |
|
| [Studies on chemical constituents from stem barks of Fraxinus paxiana]. | 2008-08 |
|
| Protective effects of salidroside against acetaminophen-induced toxicity in mice. | 2008-08 |
|
| Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. | 2008-07-07 |
|
| [Effect of salidroside on salivary adenoid cystic carcinoma cells in vitro]. | 2008-06 |
|
| Identification and comparative determination of rhodionin in traditional tibetan medicinal plants of fourteen Rhodiola species by high-performance liquid chromatography-photodiode array detection and electrospray ionization-mass spectrometry. | 2008-06 |
|
| Effects of overexpression of endogenous phenylalanine ammonia-lyase (PALrs1) on accumulation of salidroside in Rhodiola sachalinensis. | 2008-05 |
|
| Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst. | 2008-02-29 |
|
| Phenylalkanoids and monoterpene analogues from the roots of Rhodiola rosea. | 2008-02 |
|
| Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study. | 2008-01-01 |
|
| The influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice. | 2008 |
|
| Conventional and dense gas techniques for the production of liposomes: a review. | 2008 |
|
| Salidroside from Rhodiola sachalinensis protects neuronal PC12 cells against cytotoxicity induced by amyloid-beta. | 2003-08 |
Sample Use Guides
in mice: C57BL/6 mice were orally administrated salidrosid for continuous 5 days, followed by three gavages of ethanol every 30 min
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: Pretreatment of the human umbilical vein endothelial cells (HUVECs) with Salidroside (SAL) significantly reduced the cell damage effects brought by homocysteine (Hcy) in a dose-dependent manner. Functional studies on the HUVECs found that SAL rescued the endoplasmic reticulum stress induced by Hcy. The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1α).
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:17:24 GMT 2025
by
admin
on
Mon Mar 31 22:17:24 GMT 2025
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| Record UNII |
M983H6N1S9
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| Record Status |
Validated (UNII)
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| Record Version |
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741643
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DTXSID4049034
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M983H6N1S9
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Rhodioloside
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159278
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