Velmanase Alfa

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:15:45 GMT 2025` Edited by `admin` on `Mon Mar 31 21:15:45 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	M91TG242P2
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

Velmanase Alfa

Official Name

English

LAMAZYM

Preferred Name

English

MANNOSIDASE, ALPHA, CLASS 2B, MEMBER 1, RECOMBINANT

Common Name

English

VELMANASE ALFA [USAN]

Common Name

English

CHFLMZYMAA1

Code

English

Velmanase alfa [WHO-DD]

Common Name

English

R-H-LAMAN

Common Name

English

.ALPHA.-MANNOSIDASE RECOMBINANT HUMAN

Common Name

English

LYSOSOMAL ALPHA-MANNOSIDASE, RECOMBINANT

Common Name

English

RHLAMAN

Common Name

English

MANNOSIDASE, .ALPHA.-(SYNTHETIC HUMAN)

Common Name

English

velmanase alfa [INN]

Common Name

English

Human lysosomal alpha-mannosidase (Laman, EC3.2.1.24, mannosidase alpha class 2B member 1), produced in CHO (Chinese Hamster Ovary) cells, alfa glycoform

Common Name

English

A16AB

Code

English

RECOMBINANT HUMAN .ALPHA.-MANNOSIDASE

Common Name

English

CHF-LMZYMAA1

Code

English

RECOMBINANT HUMAN LAMAN

Common Name

English

Mannosidase, ?- (synthetic human)

Common Name

English

RECOMBINANT HUMAN ALPHA-MANNOSIDASE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

212005

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

NCI_THESAURUS

C29726

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

WHO-ATC

A16AB15

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

EU-Orphan Drug

EU/3/04/260

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

Code System Code Type Description

FDA UNII

M91TG242P2

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

NCI_THESAURUS

C152849

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

CAS

9025-42-7

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

GENERIC (FAMILY)

WIKIPEDIA

Velmanase alfa

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

EVMPD

SUB180967

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 3.2.1.24

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

DAILYMED

M91TG242P2

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

SMS_ID

100000166699

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

DRUG BANK

DB12374

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

CAS

1492823-75-2

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

INN

10140

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

USAN

KL-153

Created by admin on Mon Mar 31 21:15:45 GMT 2025 , Edited by admin on Mon Mar 31 21:15:45 GMT 2025

PRIMARY

From	To
1_6	1_309
1_219	1_224
1_363	1_423
1_444	1_452

Linkage Type	Residue Index
COORDINATION COMPOUND	1_23	1_25	1_147	1_397

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_84
N	1_261
N	1_318
N	1_448
N	2_43
N	2_49
N	2_90
N	2_164
N	2_230
N	3_58
N	3_107

Related Record Type Details

Velmanase Alfa-TYCV

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					M91TG242P2

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_23] [1_25] [1_147] [1_397]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	622ec997 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:GEL FILTRATION	CHEMICAL