Pegsebrenatide

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:36:45 GMT 2025` Edited by `admin` on `Wed Apr 02 00:36:45 GMT 2025`
Protein Sub Type
Record UNII	M8T7ST41L5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NLY-01

Preferred Name

English

Pegsebrenatide

Official Name

English

NLY01

Code

English

exendin-4-oyl-L-cysteinamide, conjugated at Cys 40 via a 1-O-(3-{O'-[3-(3-maleimidopropanamido)propyl]polyethylene glycol-O-yl}propylaminocarbonyl)glycerol linker with two O-methylpoly(ethylene glycol) chains

Common Name

English

pegsebrenatide [INN]

Common Name

English

Poly(oxy-1,2-ethanediyl), ?-hydro-?-hydroxy-(50KDa), ether with 2,3-dihydroxypropyl N-(3-hydroxypropyl)carbamate (3:1), C,C-dimethyl ether, 40-ether with L-histidylglycyl-L-?-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-?-aspartyl-L-leuc

Common Name

English

Code System Code Type Description

INN

12160

Created by admin on Wed Apr 02 00:36:45 GMT 2025 , Edited by admin on Wed Apr 02 00:36:45 GMT 2025

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SMS_ID

300000047333

Created by admin on Wed Apr 02 00:36:45 GMT 2025 , Edited by admin on Wed Apr 02 00:36:45 GMT 2025

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FDA UNII

M8T7ST41L5

Created by admin on Wed Apr 02 00:36:45 GMT 2025 , Edited by admin on Wed Apr 02 00:36:45 GMT 2025

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NCI_THESAURUS

C190469

Created by admin on Wed Apr 02 00:36:45 GMT 2025 , Edited by admin on Wed Apr 02 00:36:45 GMT 2025

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CAS

2243292-26-2

Created by admin on Wed Apr 02 00:36:45 GMT 2025 , Edited by admin on Wed Apr 02 00:36:45 GMT 2025

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Related Record Type Details


					EF38T7N5MI

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					M8T7ST41L5

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_40]	C-TERMINUS			Pegsebrenatide cysteinamide modification	DP300LL9AU

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL