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Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 18:47:57 GMT 2023
Edited
by admin
on Sat Dec 16 18:47:57 GMT 2023
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
M8FA2JKW5P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Rezetamig
INN  
Official Name English
JNJ-75348780
Code English
Immunoglobulin G4, anti-(human CD3 antigen) (recombinant human monoclonal JNJ-75348780 γ4-chain), disulfide with recombinant human monoclonal JNJ-75348780 κ chain, (229→126′),(232→129′)-bis(disulfide) with immunoglobulin, anti-(human sialic aci
Common Name English
immunoglobulin half G4-kappa_G4(VH-h-CH2-CH3), anti-[Homo sapiens CD3E (CD3 epsilon)] and anti-[Homo sapiens CD22 (sialic acid binding Ig-like lectin 2, SIGLEC2, SIGLEC-2, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14)], Homo sapiens monoclonal ant
Common Name English
rezetamig [INN]
Common Name English
JNJ75348780
Code English
gamma4 heavy chain anti-CD3E Homo sapiens (1-450) [VH (Homo sapiens IGHV3-9*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10,G4v4 CH2 A1.3, A1.2,G4v32 CH3 W22 (knob) (
Common Name English
Code System Code Type Description
CAS
2795115-07-8
Created by admin on Sat Dec 16 18:47:57 GMT 2023 , Edited by admin on Sat Dec 16 18:47:57 GMT 2023
PRIMARY
FDA UNII
M8FA2JKW5P
Created by admin on Sat Dec 16 18:47:57 GMT 2023 , Edited by admin on Sat Dec 16 18:47:57 GMT 2023
PRIMARY
INN
12767
Created by admin on Sat Dec 16 18:47:57 GMT 2023 , Edited by admin on Sat Dec 16 18:47:57 GMT 2023
PRIMARY
From To
3_134 3_194
3_23 3_88
2_267 2_325
2_161 2_221
2_22 2_97
1_370 1_428
1_264 1_324
1_232 2_129
1_229 2_126
1_150 1_206
1_137 3_214
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_197
Related Record Type Details
TARGET -> ACTIVATOR
Pre-clinical
TARGET->LIGAND
Pre-clinical
Related Record Type Details
ACTIVE MOIETY
JNJ-75348780 (CD22xCD3) is a humanized IgG4-PAA bispecific antibody that can act as a bridge between CD22 positive malignant B-cells and CD3 positive cytotoxic T lymphocytes (CTLs), redirecting these immune effector cells and thereby promoting the lysis of malignant B-cells with a high degree of specificity
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL