Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.4611 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](OC(=O)CC)[C@@]1(C)CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]23[H]
InChI
InChIKey=LGRKCTFWUWAKON-RRFJAZBJSA-N
InChI=1S/C21H30O3/c1-3-20(23)24-19-9-8-18-17-6-4-13-12-14(22)5-7-15(13)16(17)10-11-21(18,19)2/h12,15-19H,3-11H2,1-2H3/t15-,16+,17+,18-,19-,21-/m0/s1
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.4611 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
https://empower.pharmacy/drugs/nandrolone-decanoate-injection.html
https://us.basicstero.info/nandrolones
Curator's Comment: Description was created based on several sources, including
https://empower.pharmacy/drugs/nandrolone-decanoate-injection.html
https://us.basicstero.info/nandrolones
Nandrolone, also known as 19-nortestosterone or 19-norandrostenolone, is a semisynthetic anabolic-androgenic steroid derived from testosterone. Nandrolone is used in the form of a variety of long-acting prodrug esters for intramuscular injection, the most common of which are nandrolone decanoate. Nandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testis. Anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. Synthetic version of nandrolone was developed in 1950. But nandrolone for sale appeared later only in 1962 in the form of decanoate under the trade name Deca-Durabolin (Organon company).
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P10275 Gene ID: 367.0 Gene Symbol: AR Target Organism: Homo sapiens (Human) |
|||
Target ID: CHEMBL1871 |
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Target ID: P10275 Gene ID: 367.0 Gene Symbol: AR Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | NANDROLONE DECANOATE Approved UseNandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive. Launch Date2010 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
36.1 μg/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/10435281 |
6 mL single, oral dose: 6 mL route of administration: Oral experiment type: SINGLE co-administered: |
NANDROLONE PHENPROPIONATE blood | Sus scrofa population: HEALTHY age: UNKNOWN sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
219.9 μg × h/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/10435281 |
6 mL single, oral dose: 6 mL route of administration: Oral experiment type: SINGLE co-administered: |
NANDROLONE PHENPROPIONATE blood | Sus scrofa population: HEALTHY age: UNKNOWN sex: FEMALE / MALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| A report on alterations to the speaking and singing voices of four women following hormonal therapy with virilizing agents. | 1999 Dec |
|
| [Treatment of acute purulent mediastinitis]. | 2001 |
|
| Effects of nandrolone treatment on recovery in horses after strenuous physical exercise. | 2001 Aug |
|
| Advances in male hormonal contraception. | 2001 Dec |
|
| Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. | 2001 Dec |
|
| Anabolic steroid abuse and cardiac sudden death: a pathologic study. | 2001 Feb |
|
| Assessment of hormonally active agents in the reproductive tract of female nonhuman primates. | 2001 Jan-Feb |
|
| Detection and determination of anabolic steroids in nutritional supplements. | 2001 Jul |
|
| Doping control for nandrolone using hair analysis. | 2001 Mar |
|
| Aggression in male rats receiving anabolic androgenic steroids: effects of social and environmental provocation. | 2001 Nov |
|
| Effect of nandrolone decanoate on the lipid profile of male peritoneal dialysis patients. | 2001 Nov-Dec |
|
| Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen. | 2001 Oct |
|
| Estimation of hormone replacement therapy influence on serum galanin level in postmenopausal women. | 2001 Sep |
|
| Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. | 2001 Sep |
|
| Determination of nandrolone and metabolites in urine samples from sedentary persons and sportsmen. | 2001 Sep 25 |
|
| Effects of withdrawal from anabolic androgenic steroids on aggression in adult male rats. | 2002 Apr 1 |
|
| In situ detection and quantification of bursa of fabricius cellular proliferation or apoptosis in normal or steroid-treated neonatal chicks. | 2002 Aug |
|
| Molecular imprinted polymer coated QCM for the detection of nandrolone. | 2002 Aug |
|
| The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. | 2002 Aug 20 |
|
| Misuse of androgenic-anabolic steroids and human deltoid muscle fibers: differences between polydrug regimens and single drug administration. | 2002 Jan |
|
| Anabolic androgenic steroid affects competitive behaviour, behavioural response to ethanol and brain serotonin levels. | 2002 Jun 15 |
|
| Effect of dienogest-containing oral contraceptives on lipid metabolism. | 2002 Mar |
|
| Characterization of bone mineral composition in the proximal tibia of cynomolgus monkeys: effect of ovariectomy and nandrolone decanoate treatment. | 2002 Mar |
|
| The human ovarian surface epithelium is an androgen responsive tissue. | 2002 Mar 18 |
|
| Enzyme-assisted synthesis and structure characterization of glucuronide conjugates of methyltestosterone (17 alpha-methylandrost-4-en-17 beta-ol-3-one) and nandrolone (estr-4-en-17 beta-ol-3-one) metabolites. | 2002 Mar-Apr |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:11:04 GMT 2023
by
admin
on
Fri Dec 15 15:11:04 GMT 2023
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| Record UNII |
M86G89RH16
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| Record Status |
Validated (UNII)
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| Record Version |
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C2360
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230-587-0
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C95972
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DTXSID80992797
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7207-92-3
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Nandrolone propionate
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M86G89RH16
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m7720
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111273
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