SULAMSEROD HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H28ClN3O5S.ClH
Molecular Weight	482.422
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CS(=O)(=O)NCCN1CCC(CCC(=O)C2=CC(Cl)=C(N)C3=C2OCCO3)CC1

InChI

InChIKey=JJOQGHGEIKOGPO-UHFFFAOYSA-N

InChI=1S/C19H28ClN3O5S.ClH/c1-29(25,26)22-6-9-23-7-4-13(5-8-23)2-3-16(24)14-12-15(20)17(21)19-18(14)27-10-11-28-19;/h12-13,22H,2-11,21H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C19H28ClN3O5S
Molecular Weight	445.961
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10556228 | https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20020214&CC=WO&NR=0211766A2&KC=A2

Sulamserod is a methanesulfonamide derivative patented by British multinational pharmaceutical company GlaxoSmithKline as 5-HT4 receptor antagonist, with antiarrhythmic activities for the treatment of the certain cardiovascular condition. 5-HT4 receptor blockade could have antiarrhythmic effects by decreasing intracellular Ca2+ concentration and delayed rectifier potassium current and prolonging atrial refractory period. In preclinical models, Sulamserod prolongs mean atrial effective refractory period and wavelength, reduces the dispersion of effective refractory period, and minimally slows conduction velocity in pigs.

Originator

Approval Year

PubMed

Title	Date	PubMed
Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation.	1999 Nov 9	10556228

Patents

Sample Use Guides

In Vivo Use Guide

pig 30 mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:49 GMT 2023`
Record UNII	M6FO1M266W
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SULAMSEROD HYDROCHLORIDE

Official Name

English

RS-100302-190

Code

English

4-(2-(7-CHLORO-8-AMINO-2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)CARBONLETHYL-1-YL)-1-(2-(METHYLSULFONAMIDO)ETHYL-1-YL)-PIPERIDINE HYDROCHLORIDE

Common Name

English

SULAMSEROD HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885