Isonipecotic acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H11NO2
Molecular Weight	129.157
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1CCNCC1

InChI

InChIKey=SRJOCJYGOFTFLH-UHFFFAOYSA-N

InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)

HIDE SMILES / InChI

Molecular Formula	C6H11NO2
Molecular Weight	129.157
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles.	2009-10-07	19753350
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.	2009-08-13	19618939
Aqua-bis(4-nitro-benzoato)-κO,O';κO-(piperidinium-4-carboxyl-ato-κO,O')cadmium(II).	2009-05-20	21583026
The identification of orally bioavailable thrombopoietin agonists.	2009-03-01	19186055
Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.	2008-12-01	18926699
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.	2008-06-15	18511276
Energetic characterization of short helical polyalanine peptides in water: analysis of 13C=O chemical shift data.	2005-12-07	16316242
Temperature effects on the hydrogen-bond patterns in 4-piperidinecarboxylic acid.	2005-02	15659862
Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.	2004-12	15541505
Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists.	2004-07-16	15203141
Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists.	2004-06-01	14990676
Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.	2004-05	15120317
Synthetic methodology utilized to prepare substituted imidazole p38 MAP kinase inhibitors.	2003-11	14758763
Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.	2003-10	14609124
Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.	2003-09	13678789
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists.	2003-06	12590939
Xanthamide fluorescent dyes.	2002-12-15	12510765
Zwitterionic 4-piperidinecarboxylic acid monohydrate.	2001-08	11498628
Short, solubilized polyalanines are conformational chameleons: exceptionally helical if N- and C-capped with helix stabilizers, weakly to moderately helical if capped with rigid spacers.	2001-01-16	11148022
Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency.	2001	11226707

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:13:18 GMT 2025` Edited by `admin` on `Mon Mar 31 21:13:18 GMT 2025`
Record UNII	M5TZP1RWIE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Isonipecotic acid

Systematic Name

English

NSC-61049

Preferred Name

English

Isonipecotinic acid

Common Name

English

Piperidin-4-carboxylic acid

Systematic Name

English

Hexahydroisonicotinic acid

Systematic Name

English

ISONIPECOTIC ACID [MI]

Common Name

English

4-Carboxypiperidine

Systematic Name

English

4-Piperidinecarboxylic acid

Systematic Name

English

Code System Code Type Description

NSC

61049