ATAPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32O4
Molecular Weight	348.4764
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCC3)[C@@]1([H])C\C(C2)=C\CCCC(O)=O

InChI

InChIKey=DKLGLHQHLFISGJ-YLBFUXKPSA-N

InChI=1S/C21H32O4/c22-19(15-6-2-3-7-15)10-9-17-18-12-14(5-1-4-8-21(24)25)11-16(18)13-20(17)23/h5,9-10,15-20,22-23H,1-4,6-8,11-13H2,(H,24,25)/b10-9+,14-5+/t16-,17+,18-,19+,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H32O4
Molecular Weight	348.4764
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	2
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800002073

Ataprost (also known as ONO-41483; OP-41483), an epoprostenol agonist, participated in phase II clinical trials in Japan for the treatment patients with heart failure and myocardial ischemia. However, these trials were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:13 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:13 GMT 2023`
Record UNII	M41LMG25QB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATAPROST

Official Name

English

ataprost [INN]

Common Name

English

OP-41483

Code

English

(+)-(2E,3AS,4R,5R,6AS)-4-((1E,3S)-3-CYCLOPENTYL-3-HYDROXYPROPENYL)-3,3A,4,5,6,6A-HEXAHYDRO-5-HYDROXY-.DELTA.(SUP 2(1H),.DELTA.)-PENTALENEVALERIC ACID

Common Name

English

OP41483

Code

English

ONO41483

Code

English

ATAPROST ALFADEX [JAN]

Common Name

English

ONO-41483

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C78568