LINVOSELTAMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:38:11 GMT 2025` Edited by `admin` on `Tue Apr 01 22:38:11 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	M3CPC50MZS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LINVOSELTAMAB

Official Name

English

REGN-5458

Preferred Name

English

Human IgG4-based anti-CD3 x anti-BCMA bispecific monoclonal antibody that binds to CD3 and BCMA

Common Name

English

IMMUNOGLOBULIN G4 (103-CYSTEINE,108-CYSTEINE,233-PROLINE,238-PROLINE,239-VALINE,240-ALANINE,DE-241-GLYCINE), ANTI-(HUMAN B-CELL MATURATION ANTIGEN) (HUMAN MONOCLONAL REGN5458 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL REGN5458 .KAPPA.-CHAIN, (231->

Common Name

English

linvoseltamab [INN]

Common Name

English

REGN5458

Code

English

LINVOSELTAMAB [USAN]

Common Name

English

Linvoseltamab [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

882022

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

Code System Code Type Description

SMS_ID

300000038669

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

PRIMARY

FDA UNII

M3CPC50MZS

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

PRIMARY

USAN

JK-13

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

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INN

12104

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

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CAS

2408319-25-3

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

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NCI_THESAURUS

C158504

Created by admin on Tue Apr 01 22:38:11 GMT 2025 , Edited by admin on Tue Apr 01 22:38:11 GMT 2025

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From	To
1_22	1_96
1_103	1_108
1_139	3_215
1_152	1_208
1_231	2_230
1_234	2_233
1_265	1_325
1_371	1_429
2_22	2_96
2_138	4_215
2_151	2_207
2_264	2_324
2_370	2_428
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_300

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL