DPC-684

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H48FN5O5S
Molecular Weight	669.85
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN(C[C@@H](O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNCC2=CC(F)=CC=C2)C(C)(C)C)S(=O)(=O)C3=CC=C(N)C=C3

InChI

InChIKey=IXZYCIFRVZKVRJ-RKKDRKJOSA-N

InChI=1S/C35H48FN5O5S/c1-24(2)22-41(47(45,46)29-16-14-28(37)15-17-29)23-31(42)30(19-25-10-7-6-8-11-25)39-34(44)33(35(3,4)5)40-32(43)21-38-20-26-12-9-13-27(36)18-26/h6-18,24,30-31,33,38,42H,19-23,37H2,1-5H3,(H,39,44)(H,40,43)/t30-,31+,33+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C35H48FN5O5S
Molecular Weight	669.85
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:28:26 GMT 2023` Edited by `admin` on `Sat Dec 16 11:28:26 GMT 2023`
Record UNII	M2H3KFV7W5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DPC-684

Code

English

DPH-140662

Code

English

L-VALINAMIDE, N-((3-FLUOROPHENYL)METHYL)GLYCYL-N-((1S,2R)-3-(((4-AMINOPHENYL)SULFONYL)(2-METHYLPROPYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-METHYL-

Systematic Name

English

DPC684

Code

English

(2S)-N-((1S,2R)-3-((4-AMINOPHENYL)SULFONYL-ISOBUTYL-AMINO)-1-BENZYL-2-HYDROXY-PROPYL)-2-((2-((3-FLUOROPHENYL)METHYLAMINO)ACETYL)AMINO)-3,3-DIMETHYL-BUTANAMIDE

Systematic Name

English

N-((3-FLUOROPHENYL)METHYL)GLYCYL-N-((1S,2R)-3-(((4-AMINOPHENYL)SULFONYL)(2-METHYLPROPYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-METHYL-L-VALINAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

464031

Created by admin on Sat Dec 16 11:28:26 GMT 2023 , Edited by admin on Sat Dec 16 11:28:26 GMT 2023

PRIMARY

MANUFACTURER PRODUCT INFORMATION

DPC-684

Created by admin on Sat Dec 16 11:28:26 GMT 2023 , Edited by admin on Sat Dec 16 11:28:26 GMT 2023

PRIMARY

Registry Number: 367281-53-6; Synonyms: DPC 684, DPC-684, AIDS041322, AIDS-041322, CID464031, 367281-53-6, 284661-73-0

FDA UNII

M2H3KFV7W5

Created by admin on Sat Dec 16 11:28:26 GMT 2023 , Edited by admin on Sat Dec 16 11:28:26 GMT 2023

PRIMARY

CAS

284661-73-0

Created by admin on Sat Dec 16 11:28:26 GMT 2023 , Edited by admin on Sat Dec 16 11:28:26 GMT 2023

PRIMARY

Related Record Type Details


					XQU9H7JLN5

DPC-684 DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

Chemical synthesis of compound.

Related Record Type Details


					M2H3KFV7W5

DPC-684

ACTIVE MOIETY

Comments:

A panel of chimeric viruses constructed from clinical samples from patients who failed PI-containing regimens and containing 5 to 11 mutations, including positions 10, 32, 46, 47, 50, 54, 63, 71, 82, 84, and 90 had mean IC50 values of <20 nM for DPC 681 and DPC 681, respectively.