Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C20H23N7O6.H2O4S |
| Molecular Weight | 1012.958 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(O)(=O)=O.[H][C@@]12CN(CN1C3=C(NC2)NC(N)=NC3=O)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(O)=O)C(O)=O.[H][C@@]56CN(CN5C7=C(NC6)NC(N)=NC7=O)C8=CC=C(C=C8)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI
InChIKey=KHQZYLZNYVRXOD-NVGTXZLJSA-N
InChI=1S/2C20H23N7O6.H2O4S/c2*21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29;1-5(2,3)4/h2*1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31);(H2,1,2,3,4)/t2*12-,13+;/m11./s1
| Molecular Formula | H2O4S |
| Molecular Weight | 98.078 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C20H23N7O6 |
| Molecular Weight | 457.4399 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
METHYLENETETRAHYDROFOLIC ACID, L-(+), an endogenous biomodulator that was developed under the brand name modufolin or arfolitixorin by the Isofol Medical. Arfolitixorin is developed to increase the efficacy of standard of care chemotherapy for advanced colorectal cancer. This drug is currently being studied in a global phase 3 clinical trial. Besides, the drug successfully completed phase II as rescue therapy for osteosarcoma. 21 May 2019 Isofol Medical has received clinical patent protection for the arfolitixorinin USA. It relates to a method of increasing blood concentration of deoxyuridine, a blood biomarker for inhibition of tumor growth in human cancer treatment.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:42:39 GMT 2023
by
admin
on
Sat Dec 16 14:42:39 GMT 2023
|
| Record UNII |
LZ73JVT65C
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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LZ73JVT65C
Created by
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1654736-73-8
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135564976
Created by
admin on Sat Dec 16 14:42:40 GMT 2023 , Edited by admin on Sat Dec 16 14:42:40 GMT 2023
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100000170615
Created by
admin on Sat Dec 16 14:42:40 GMT 2023 , Edited by admin on Sat Dec 16 14:42:40 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |