Gulgafafusp Alfa

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:55:02 GMT 2025` Edited by `admin` on `Wed Apr 02 16:55:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Type	COMPLETE
Record UNII	LYK65H95KT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GMA-102

Preferred Name

English

Gulgafafusp Alfa

Official Name

English

humanized monoclonal antibody fusion with human Glucagon-like peptide 1 (GLP1); Type: IgG2-kappa; antigen: human glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R (GLP1R); CDR source: Mus musculus (humanized by Kabat CDR grafting); heavy

Common Name

English

Immunoglobulin G2, anti-(human glucagon-like peptide-1 receptor) (human-Mus musculus monoclonal GMA102 ?2-chain), disulfide with 1-29-glucagon-like peptide-1 (human) fusion protein with peptide linker (GSGSATGGSGSGASSGSGSATGS) fusion protein with human-M

Common Name

English

gulgafafusp alfa [INN]

Common Name

English

GMA102

Code

English

Code System Code Type Description

SMS_ID

300000050028

Created by admin on Wed Apr 02 16:55:02 GMT 2025 , Edited by admin on Wed Apr 02 16:55:02 GMT 2025

PRIMARY

INN

12332

Created by admin on Wed Apr 02 16:55:02 GMT 2025 , Edited by admin on Wed Apr 02 16:55:02 GMT 2025

PRIMARY

FDA UNII

LYK65H95KT

Created by admin on Wed Apr 02 16:55:02 GMT 2025 , Edited by admin on Wed Apr 02 16:55:02 GMT 2025

PRIMARY

NCI_THESAURUS

C199206

Created by admin on Wed Apr 02 16:55:02 GMT 2025 , Edited by admin on Wed Apr 02 16:55:02 GMT 2025

PRIMARY

CAS

2642374-02-3

Created by admin on Wed Apr 02 16:55:02 GMT 2025 , Edited by admin on Wed Apr 02 16:55:02 GMT 2025

PRIMARY

From	To
4_186	4_246
4_75	4_140
3_186	3_246
3_75	3_140
3_139	4_266
2_139	2_429
2_371	4_139
2_265	2_325
2_152	2_208
2_22	2_96
1_234	2_234
1_231	2_231
1_228	2_228
1_227	2_227
1_139	3_266
1_371	1_429
1_265	1_325
1_152	1_208
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					EF38T7N5MI

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					LYK65H95KT

Gulgafafusp Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]				PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL