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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H32O5
Molecular Weight 376.4865
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of BLXA4

SMILES

CCCCC[C@@H](O)\C=C\C1=C(/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O)C=CC=C1

InChI

InChIKey=HEDVTGFTYROYFE-RREUNBNVSA-N
InChI=1S/C22H32O5/c1-2-3-4-10-19(23)15-13-17-8-5-6-9-18(17)14-16-21(25)20(24)11-7-12-22(26)27/h5-6,8-9,13-16,19-21,23-25H,2-4,7,10-12H2,1H3,(H,26,27)/b15-13+,16-14+/t19-,20+,21-/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H32O5
Molecular Weight 376.4865
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 2
Optical Activity UNSPECIFIED

Benzo-lipoxin A4 as a bLXA4-ME also known as ClinRinse-1 participated in phase II clinical trials for the treatment of gingival diseases. It was shown that nano-proresolving medicines (NPRM) containing a lipoxin analog (benzo-lipoxin A4, bLXA4) was a mimetic of endogenous resolving mechanisms with potent bioactions. That offered a new therapeutic tissue-engineering approach for the treatment of chronic osteolytic inflammatory diseases.

Approval Year

PubMed

PubMed

TitleDatePubMed
Proresolving nanomedicines activate bone regeneration in periodontitis.
2015 Jan
Patents

Sample Use Guides

The topical oral rinse dosage form of BLXA4-ME (also known as ClinRinse-1) will consist of drug substance prepared at a concentration of 1.0 μM in an aqueous vehicle solution
Route of Administration: Dental
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:29:35 GMT 2023
Edited
by admin
on Sat Dec 16 09:29:35 GMT 2023
Record UNII
LXE89WJ787
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BLXA4
Common Name English
BLXA-4
Code English
7-OCTENOIC ACID, 5,6-DIHYDROXY-8-(2-((1E,3R)-3-HYDROXY-1-OCTEN-1-YL)PHENYL)-, (5S,6R,7E)-
Systematic Name English
BENZO-LIPOXIN A4
Common Name English
BENZO-LXA4
Common Name English
BENZO-LXA-4
Common Name English
7-OCTENOIC ACID, 5,6-DIHYDROXY-8-(2-((1E,3R)-3-HYDROXY-1-OCTENYL)PHENYL)-, (5S,6R,7E)-
Systematic Name English
Code System Code Type Description
CAS
864516-86-9
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY
FDA UNII
LXE89WJ787
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY
PUBCHEM
58185197
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY
DRUG BANK
DB12133
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY