Spevatamig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:30:53 GMT 2025` Edited by `admin` on `Wed Apr 02 14:30:53 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	LVB74L4PM2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PT-886

Preferred Name

English

Spevatamig

Official Name

English

H-gamma1 heavy chain anti-CD47 (1-444), G1v92-1 VH E44, CH1 E77 [VH E44 (Homo sapiens IGHV1-46*01 (87.6%) Q44>E (39') -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, CH1 E77

Common Name

English

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-kappa), anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3) and anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, SFTPJ, surfactant associated protein J) isoform 2], bispecif

Common Name

English

Immunoglobulin G1 [168-lysine,351-cysteine,368-serine,370-alanine,409-valine], anti-(human claudin CLDN18.2) (human-Mus musculus monoclonal PT886 ?1-chain), disulfide with [120-glutamic acid] human-Mus musculus monoclonal PT886 ?-chain, (228?223?),(231?2

Common Name

English

spevatamig [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

888122