Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C9H12ClNO3S |
| Molecular Weight | 249.714 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1
InChI
InChIKey=JYLNVJYYQQXNEK-UHFFFAOYSA-N
InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
| Molecular Formula | C9H12ClNO3S |
| Molecular Weight | 249.714 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. | 1997 Mar 20 |
|
| Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine. | 2001 Jul |
|
| gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats. | 2001 Jul 6 |
|
| Gamma-vinyl GABA reduces paired pulse inhibition in the rat dentate gyrus in vivo and in vitro. | 2001 May |
|
| Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats. | 2001 Nov |
|
| Synaptic regulation of somatodendritic dopamine release by glutamate and GABA differs between substantia nigra and ventral tegmental area. | 2002 Apr |
|
| Pentobarbital depressant effects are independent of GABA receptors in auditory thalamic neurons. | 2002 Dec |
|
| Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. | 2002 Jan |
|
| Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum. | 2002 Jul |
|
| International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. | 2002 Jun |
|
| Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression. | 2002 Mar |
|
| Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. | 2002 Sep |
|
| Biphasic effect of GABA on rat sperm acrosome reaction: involvement of GABA(A) and GABA(B) receptors. | 2002 Sep-Oct |
|
| Lack of intersite GABA receptor subtype antagonist effects upon mu opioid receptor agonist-induced feeding elicited from either the ventral tegmental area or nucleus accumbens shell in rats. | 2003 Jul |
|
| Dual effect of GABA on descending monosynaptic excitatory postsynaptic potential in frog lumbar motoneurons. | 2004 |
|
| GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of short-term synaptic plasticity. | 2004 May |
|
| Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat. | 2005 May 9 |
|
| Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain. | 2005 Oct 31 |
|
| Nitric oxide modulates the firing rate of the rat supraoptic magnocellular neurons. | 2008 Aug 13 |
|
| GABAB receptors role in cell migration and positioning within the ventromedial nucleus of the hypothalamus. | 2008 Feb 19 |
|
| GABAB receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats. | 2008 Jan 29 |
|
| Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats. | 2008 Jul |
|
| GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. | 2008 Mar |
|
| [Cardiovascular change induced by central hypertonic saline are accompanied by GABA release in awake rats]. | 2009 Nov |
|
| Human cord blood-derived hematopoietic and neural-like stem/progenitor cells are attracted by the neurotransmitter GABA. | 2009 Nov |
|
| GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state. | 2010 Dec 15 |
|
| Effect of sildenafil on neuropathic pain and hemodynamics in rats. | 2010 Jan |
|
| 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra. | 2010 Jan 13 |
|
| GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions. | 2010 Oct 8 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:57:45 UTC 2023
by
admin
on
Sat Dec 16 10:57:45 UTC 2023
|
| Record UNII |
LRZ36BCQ1Y
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
Download
| Name | Type | Language | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DTXSID90903970
Created by
admin on Sat Dec 16 10:57:45 UTC 2023 , Edited by admin on Sat Dec 16 10:57:45 UTC 2023
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PRIMARY | |||
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125464-42-8
Created by
admin on Sat Dec 16 10:57:45 UTC 2023 , Edited by admin on Sat Dec 16 10:57:45 UTC 2023
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122150
Created by
admin on Sat Dec 16 10:57:45 UTC 2023 , Edited by admin on Sat Dec 16 10:57:45 UTC 2023
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PRIMARY | |||
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Saclofen
Created by
admin on Sat Dec 16 10:57:45 UTC 2023 , Edited by admin on Sat Dec 16 10:57:45 UTC 2023
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PRIMARY | |||
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LRZ36BCQ1Y
Created by
admin on Sat Dec 16 10:57:45 UTC 2023 , Edited by admin on Sat Dec 16 10:57:45 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE ENANTIOMER->RACEMATE | |||
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TARGET -> INHIBITOR |
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