Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C9H12ClNO3S |
| Molecular Weight | 249.714 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1
InChI
InChIKey=JYLNVJYYQQXNEK-UHFFFAOYSA-N
InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
| Molecular Formula | C9H12ClNO3S |
| Molecular Weight | 249.714 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state. | 2010-12-15 |
|
| GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions. | 2010-10-08 |
|
| Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems. | 2010-09 |
|
| Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats. | 2010-08 |
|
| A pressurized nitrogen counterbalance to cortical glutamatergic pathway stimulation. | 2010-05 |
|
| Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats. | 2010-03-31 |
|
| 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra. | 2010-01-13 |
|
| Effect of sildenafil on neuropathic pain and hemodynamics in rats. | 2010-01 |
|
| IH current generates the afterhyperpolarisation following activation of subthreshold cortical synaptic inputs to striatal cholinergic interneurons. | 2009-12-15 |
|
| [Cardiovascular change induced by central hypertonic saline are accompanied by GABA release in awake rats]. | 2009-11 |
|
| Human cord blood-derived hematopoietic and neural-like stem/progenitor cells are attracted by the neurotransmitter GABA. | 2009-11 |
|
| Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward. | 2009-02 |
|
| Role of ventral medial prefrontal cortex in incubation of cocaine craving. | 2009 |
|
| Nitric oxide modulates the firing rate of the rat supraoptic magnocellular neurons. | 2008-08-13 |
|
| Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats. | 2008-07 |
|
| GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. | 2008-03 |
|
| GABAB receptors role in cell migration and positioning within the ventromedial nucleus of the hypothalamus. | 2008-02-19 |
|
| GABAB receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats. | 2008-01-29 |
|
| Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer. | 2008 |
|
| GABA(B) receptor activation inhibits dopamine D1 receptor-mediated facilitation of [(3)H]GABA release in substantia nigra pars reticulata. | 2007-10 |
|
| A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice. | 2007-10 |
|
| Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. | 2007-06-13 |
|
| Pentobarbital enhances gamma-aminobutyric acid-mediated excitation without altering synaptic plasticity in rat hippocampus. | 2007-04 |
|
| Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis. | 2007-03-02 |
|
| Opposite effects of presynaptic 5-HT3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses. | 2007-01 |
|
| Orexin A in the rostrolateral hypothalamic area induces feeding by modulating GABAergic transmission. | 2006-12-13 |
|
| Baclofen, an agonist at peripheral GABAB receptors, induces antinociception via activation of TEA-sensitive potassium channels. | 2006-11 |
|
| GABA receptor subtype antagonists in the nucleus accumbens shell and ventral tegmental area differentially alter feeding responses induced by deprivation, glucoprivation and lipoprivation in rats. | 2006-04-12 |
|
| Simultaneous NMDA-dependent long-term potentiation of EPSCs and long-term depression of IPSCs in cultured rat hippocampal neurons. | 2006-01-25 |
|
| Analysis of responses to kava kava in the feline pulmonary vascular bed. | 2006 |
|
| Involvement of spinal GABA receptors in the regulation of intraspinal acetylcholine release. | 2005-11-21 |
|
| GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats. | 2005-11 |
|
| Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain. | 2005-10-31 |
|
| Enantiomeric analysis of baclofen analogs by capillary zone electrophoresis, using highly sulfated cyclodextrins: Inclusion ionization constant pKa determination. | 2005-08 |
|
| Involvement of kv1 potassium channels in spreading acidification and depression in the cerebellar cortex. | 2005-08 |
|
| GABAB receptors on central terminals of C-afferents mediate intersegmental Adelta-afferent evoked hypoalgesia. | 2005-06 |
|
| Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat. | 2005-05-09 |
|
| Functional GABA(B) receptors are expressed at the cone photoreceptor terminals in bullfrog retina. | 2005 |
|
| Human follicular fluid stimulates the sperm acrosome reaction by interacting with the gamma-aminobutyric acid receptors. | 2004-10 |
|
| Analysis of gamma-aminobutyric acid-mediated responses in the pulmonary vascular bed of the cat. | 2004-09 |
|
| A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats. | 2004-08-04 |
|
| Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue. | 2004-05-01 |
|
| GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of short-term synaptic plasticity. | 2004-05 |
|
| GABA modulates presynaptic signalling mediated by dinucleotides on rat synaptic terminals. | 2004-03 |
|
| Dopaminergic ventral tegmental neurons modulated by methylphenidate. | 2004-02-13 |
|
| Analysis of responses to St. John's Wort in the feline pulmonary vascular bed. | 2004 |
|
| Dual effect of GABA on descending monosynaptic excitatory postsynaptic potential in frog lumbar motoneurons. | 2004 |
|
| Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons. | 2004 |
|
| Analysis of responses to valerian root extract in the feline pulmonary vascular bed. | 2003-12 |
|
| Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. | 1997-03-20 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:32:26 GMT 2025
by
admin
on
Mon Mar 31 23:32:26 GMT 2025
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| Record UNII |
LRZ36BCQ1Y
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID90903970
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125464-42-8
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122150
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Saclofen
Created by
admin on Mon Mar 31 23:32:26 GMT 2025 , Edited by admin on Mon Mar 31 23:32:26 GMT 2025
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LRZ36BCQ1Y
Created by
admin on Mon Mar 31 23:32:26 GMT 2025 , Edited by admin on Mon Mar 31 23:32:26 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE ENANTIOMER->RACEMATE | |||
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TARGET -> INHIBITOR |
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