7-ETHYLCAMPTOTHECIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H20N2O4
Molecular Weight	376.4052
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=C2CN3C(=CC4=C(COC(=O)[C@]4(O)CC)C3=O)C2=NC5=CC=CC=C15

InChI

InChIKey=MYQKIWCVEPUPIL-QFIPXVFZSA-N

InChI=1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H20N2O4
Molecular Weight	376.4052
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase I 59 Target ID: CHEMBL1781 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10648633	Inhibitor 8297		4.44 µM [EC50]

PubMed

Title	Date	PubMed
7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents.	2000 Feb	10648633

Substance Class	Chemical Created by `admin` on `Sat Dec 16 19:04:06 GMT 2023` Edited by `admin` on `Sat Dec 16 19:04:06 GMT 2023`
Record UNII	LPY7FE51IW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

7-ETHYLCAMPTOTHECIN

Common Name

English

1H-PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4,11-DIETHYL-4-HYDROXY-, (4S)-

Systematic Name

English

7-ETHYLCAMPTOTHECIN [USP IMPURITY]

Common Name

English

1H-PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4,11-DIETHYL-4-HYDROXY-, (S)-

Systematic Name

English

7-ETHYL-20(S)-CAMPTOTHECIN

Common Name

English

IRINOTECAN RELATED COMPOUND E [USP-RS]

Common Name

English

SN 22

Common Name

English

(S)-4,11-DIETHYL-4-HYDROXY-1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUIN OLINE-3,14(4H,12H)-DIONE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID60228960