U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:24:15 GMT 2025
Edited
by admin
on Tue Apr 01 18:24:15 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
LLJ6UPO71A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HEPATOCYTE NOS
Preferred Name English
NITRIC OXIDE SYNTHASE, INDUCIBLE
Common Name English
PEPTIDYL-CYSTEINE S-NITROSYLASE NOS2
Common Name English
NOS type II
Common Name English
NOS2A
Common Name English
INDUCIBLE NO SYNTHASE
Common Name English
Code System Code Type Description
FDA UNII
LLJ6UPO71A
Created by admin on Tue Apr 01 18:24:15 GMT 2025 , Edited by admin on Tue Apr 01 18:24:15 GMT 2025
PRIMARY
UNIPROT
P35228
Created by admin on Tue Apr 01 18:24:15 GMT 2025 , Edited by admin on Tue Apr 01 18:24:15 GMT 2025
PRIMARY
Related Record Type Details
INDUCER -> TARGET
WEAK INHIBITOR->TARGET
INHIBITOR OF EXPRESSION->TARGET
INHIBITOR -> TARGET
Slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). Inhibited enzyme did not recover activity after 2 h. Thus, 1400W was either an irreversible inhibitor or an extremely slowly reversible inhibitor of human iNOS with a Kd value ? 7 nM.
TIME-DEPENDENT INHIBITION
Ki
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_234] [1_578] [1_892] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_575] TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL