Rilogrotug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:55:59 GMT 2025` Edited by `admin` on `Wed Apr 02 09:55:59 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	LI86LS4ZUR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Rilogrotug

Official Name

English

AV-380

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens Growth/differentiation factor 15 (GDF15), Macrophage inhibitory cytokine 1 (MIC-1)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-69*02 (83.7%) -(IGHD) -IGHJ4*01 (

Common Name

English

RILOGROTUG [USAN]

Common Name

English

Immunoglobulin G1, anti-(human growth differentiation factor 15) (human-Mus musculus monoclonal AV-380 ?1-chain), disulfide with human-Mus musculus monoclonal AV-380 ?-chain, dimer

Common Name

English

AV-380 (GDF15 MAB)

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C200801

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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FDA UNII

LI86LS4ZUR

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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INN

13236

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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USAN

LM-218

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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CAS

2894138-72-6

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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SMS_ID

300000054728

Created by admin on Wed Apr 02 09:55:59 GMT 2025 , Edited by admin on Wed Apr 02 09:55:59 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					1W0AX7Y5YC

GROWTH/DIFFERENTIATION FACTOR 15

TARGET -> INHIBITOR

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					LI86LS4ZUR

ACTIVE MOIETY

Interaction Type:

IN-VITRO

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]				PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL