FLESTOLOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H22FN3O4
Molecular Weight	327.3513
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FLESTOLOL

Structure Search

SMILES

CC(C)(CNC(N)=O)NCC(O)COC(=O)C1=C(F)C=CC=C1

InChI

InChIKey=ZPLOQFLCMVIWRY-UHFFFAOYSA-N

InChI=1S/C15H22FN3O4/c1-15(2,9-18-14(17)22)19-7-10(20)8-23-13(21)11-5-3-4-6-12(11)16/h3-6,10,19-20H,7-9H2,1-2H3,(H3,17,18,22)

HIDE SMILES / InChI

Molecular Formula	C15H22FN3O4
Molecular Weight	327.3513
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67047847 | https://www.ncbi.nlm.nih.gov/pubmed/2870085 | https://www.ncbi.nlm.nih.gov/pubmed/2868646

FLESTOLOL is an ultra-short-acting beta-adrenergic blocking agent without any intrinsic sympathomimetic activity.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Flestolol: an ultra-short-acting beta-adrenergic blocking agent.	1986 Mar	2870085
Tolerance and beta-adrenergic blocking activity of flestolol, a short-acting beta blocker.	1986 May	3698462
Antiarrhythmic activity of flestolol, a novel ultra-short-acting beta-adrenoceptor antagonist, in the dog.	1986 Nov 12	2880726
Pharmacokinetics and pharmacodynamics of flestolol, a new short-acting, beta-adrenergic receptor antagonist.	1987 Jan	2890664

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:27 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:27 UTC 2023`
Record UNII	LI02075E1W
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLESTOLOL

Official Name

English

BENZOIC ACID, 2-FLUORO-, 3-((2-((AMINOCARBONYL)AMINO)-1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPYL ESTER

Systematic Name

English

ACC-9089

Code

English

BENZOIC ACID, 2-FLUORO-, 3-((2-((AMINOCARBONYL)AMINO)-1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPYL ESTER, (±)-

Common Name

English

O-FLUOROBENZOIC ACID, 3-ESTER WITH (±)-(2-((2,3-DIHYDROXYPROPYL)AMINO)-2-METHYLPROPYL)UREA

Common Name

English

flestolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

Code System Code Type Description

CAS

87721-62-8

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

EVMPD

SUB07641MIG

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

INN

5760

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

FDA UNII

LI02075E1W

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

NCI_THESAURUS

C72784

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

CAS

91697-99-3

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

SUPERSEDED

ChEMBL

CHEMBL7467

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

WIKIPEDIA

Flestolol

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

EPA CompTox

DTXSID60868981

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

SMS_ID

100000080994

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

PUBCHEM

55885

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

MESH

C047847

Created by admin on Fri Dec 15 16:12:27 UTC 2023 , Edited by admin on Fri Dec 15 16:12:27 UTC 2023

PRIMARY

Related Record Type Details


					T5MWT8445U

FLESTOLOL SULFATE

SALT/SOLVATE -> PARENT


					V8FW2XAC43

FLESTOLOL, (+)-

ENANTIOMER -> RACEMATE


					39WX8P569M

FLESTOLOL, (-)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					LI02075E1W

FLESTOLOL

ACTIVE MOIETY