OMFILOCTOCOG ALFA (HUMAN GLYCOSYLATION)

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:00:13 GMT 2025` Edited by `admin` on `Wed Apr 02 08:00:13 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	LHS5C0QQH8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OMFILOCTOCOG ALFA (HUMAN GLYCOSYLATION)

Official Name

English

1-740-BLOOD COAGULATION FACTOR VIII (RECOMBINANT HUMAN SCT800 HEAVY CHAIN) FUSION PROTEIN WITH HUMAN BLOOD COAGULATION FACTOR VIII B DOMAIN FRAGMENT (14-AMINO ACID LINKER) FUSION PROTEIN WITH BLOOD COAGULATION FACTOR VIII (RECOMBINANT HUMAN SCT800 LIGHT

Preferred Name

English

HUMAN COAGULATION FACTOR VIII (FVIII, ANTIHEMOPHILIC FACTOR, AHF, PROCOAGULANT COMPONENT) WITH DELETED B-DOMAIN (746-1639)-, SEQUENCE: SINGLE-CHAIN RECOMBINANT FVIII COMPOSED OF DOMAINS A1-A1-A2-A2 (1-740), THE B-DOMAIN N-AND C-TERMINAL FRAGMENTS (741-74

Common Name

English

Code System Code Type Description

CAS

2249927-58-8

Created by admin on Wed Apr 02 08:00:13 GMT 2025 , Edited by admin on Wed Apr 02 08:00:13 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

FDA UNII

LHS5C0QQH8

Created by admin on Wed Apr 02 08:00:13 GMT 2025 , Edited by admin on Wed Apr 02 08:00:13 GMT 2025

PRIMARY

INN

11213

Created by admin on Wed Apr 02 08:00:13 GMT 2025 , Edited by admin on Wed Apr 02 08:00:13 GMT 2025

PRIMARY

From	To
1_153	1_179
1_248	1_329
1_528	1_554
1_630	1_711
1_938	1_964
1_1005	1_1009
1_1280	1_1432
1_1127	1_1275

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_41
N	1_239
N	1_916
N	1_1224

Related Record Type Details


					681K1JDI8M

VALOCTOCOGENE ROXAPARVOVEC

VECTOR->EXPRESSED PROTEIN

Amount:

Related Record Type Details


					LHS5C0QQH8

OMFILOCTOCOG ALFA (HUMAN GLYCOSYLATION)

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_346] [1_718] [1_719] [1_723] [1_770] [1_786]	SITE_SPECIFIC			TYROSINE O-SULFATE	29166358BF

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL