4'-HYDROXY-2,3,4,5-TETRACHLOROBIPHENYL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H6Cl4O
Molecular Weight	307.987
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 4'-HYDROXY-2,3,4,5-TETRACHLOROBIPHENYL

Structure Search

SMILES

OC1=CC=C(C=C1)C2=CC(Cl)=C(Cl)C(Cl)=C2Cl

InChI

InChIKey=RESKVBRHSNTJNG-UHFFFAOYSA-N

InChI=1S/C12H6Cl4O/c13-9-5-8(10(14)12(16)11(9)15)6-1-3-7(17)4-2-6/h1-5,17H

HIDE SMILES / InChI

Molecular Formula	C12H6Cl4O
Molecular Weight	307.987
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay.	2015-10	26231822
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.	2015-02	25349334
Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.	2012-11-19	23013281
Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.	2007-03	17322771
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.	2007-01	17141713
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006-11	16497524
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.	2006-02	16413991
Long-term effects of neonatal exposure to hydroxylated polychlorinated biphenyls in the BALB/cCrgl mouse.	2005-08	16079073
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.	2004-12	15610856
Free energies of binding of polychlorinated biphenyls to the estrogen receptor from a single simulation.	2004-02-01	14696186
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.	2003-10	14565775
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.	2001-07	11530281
4-hydroxy-2',4',6'-trichlorobiphenyl and 4-hydroxy-2',3',4',5'-tetrachlorobiphenyl are estrogenic in rainbow trout.	2001-02	11351435
Toxicology of environmental estrogens.	2001	11800169
Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta.	2000-11-17	10964929
Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast.	1997-04-07	9144411
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.	1997-01	9007045

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:48:22 GMT 2025` Edited by `admin` on `Mon Mar 31 20:48:22 GMT 2025`
Record UNII	LH750S39FX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(1,1'-BIPHENYL)-4-OL, 2',3',4',5'-TETRACHLORO-

Preferred Name

English

4'-HYDROXY-2,3,4,5-TETRACHLOROBIPHENYL

Systematic Name

English

2,3,4,5-TETRACHLORO-4'-BIPHENYLOL

Systematic Name

English

2',3',4',5'-TETRACHLORO-(1,1'-BIPHENYL)-4-OL

Systematic Name

English

2',3',4',5'-TETRACHLOROBIPHENYL-4-OL

Systematic Name

English

Code System Code Type Description

PUBCHEM

105101