U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:57:53 GMT 2023
Edited
by admin
on Sat Dec 16 11:57:53 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
LGU8Z0A50H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1
Common Name English
OTRPC1
Common Name English
CAPSAICIN RECEPTOR
Common Name English
TRPV1
Common Name English
VR1
Common Name English
OSM-9-LIKE TRP CHANNEL 1
Common Name English
VANILLOID RECEPTOR 1
Common Name English
Code System Code Type Description
PHAROS
Q8NER1
Created by admin on Sat Dec 16 11:57:54 GMT 2023 , Edited by admin on Sat Dec 16 11:57:54 GMT 2023
PRIMARY
UNIPROT
Q8NER1
Created by admin on Sat Dec 16 11:57:54 GMT 2023 , Edited by admin on Sat Dec 16 11:57:54 GMT 2023
PRIMARY
WIKIPEDIA
TRPV1
Created by admin on Sat Dec 16 11:57:54 GMT 2023 , Edited by admin on Sat Dec 16 11:57:54 GMT 2023
PRIMARY
FDA UNII
LGU8Z0A50H
Created by admin on Sat Dec 16 11:57:54 GMT 2023 , Edited by admin on Sat Dec 16 11:57:54 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_604
Related Record Type Details
AGONIST -> TARGET
16,000,000 Scoville units same as Capsaicin
INHIBITOR -> TARGET
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
IC50
ACTIVATOR -> TARGET
QX-314 directly activates TRPV1 and TRPA1 channels leading to a subsequent calcium influx (figs. 3A and 4A). It has been demonstrated that TRPV1-mediated calcium influx triggers apoptosis-like cascade leading to cell death.
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
TRPV1 IC50 based on inhibition of calcium flux in response to 50 nM capsaicin in human TRPV1 stably expressed in human astrocytoma 1321 cells.
INHIBITOR
IC50
AGONIST -> TARGET
MODULATOR->TARGET
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
TRPV1 IC50 based on inhibition of calcium flux in response to 50 nM capsaicin in human TRPV1 stably expressed in human astrocytoma 1321 cells.
INHIBITOR
IC50
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Appears to be 5 times more active in preventing seizures than cannabidiol.
AGONIST -> TARGET
9,100,000 Scoville units
INHIBITOR -> TARGET
INHIBITOR
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL