U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 11:57:53 UTC 2023
Edited
by admin
on Sat Dec 16 11:57:53 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
LGU8Z0A50H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1
Common Name English
OTRPC1
Common Name English
CAPSAICIN RECEPTOR
Common Name English
TRPV1
Common Name English
VR1
Common Name English
OSM-9-LIKE TRP CHANNEL 1
Common Name English
VANILLOID RECEPTOR 1
Common Name English
Code System Code Type Description
PHAROS
Q8NER1
Created by admin on Sat Dec 16 11:57:54 UTC 2023 , Edited by admin on Sat Dec 16 11:57:54 UTC 2023
PRIMARY
UNIPROT
Q8NER1
Created by admin on Sat Dec 16 11:57:54 UTC 2023 , Edited by admin on Sat Dec 16 11:57:54 UTC 2023
PRIMARY
WIKIPEDIA
TRPV1
Created by admin on Sat Dec 16 11:57:54 UTC 2023 , Edited by admin on Sat Dec 16 11:57:54 UTC 2023
PRIMARY
FDA UNII
LGU8Z0A50H
Created by admin on Sat Dec 16 11:57:54 UTC 2023 , Edited by admin on Sat Dec 16 11:57:54 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_604
Related Record Type Details
Structure of DIHYDROCAPSAICIN
AGONIST -> TARGET
16,000,000 Scoville units same as Capsaicin
Structure of MOTUGIVATREP
INHIBITOR -> TARGET
Structure of MAVATREP
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
IC50
Structure of QX-314
ACTIVATOR -> TARGET
QX-314 directly activates TRPV1 and TRPA1 channels leading to a subsequent calcium influx (figs. 3A and 4A). It has been demonstrated that TRPV1-mediated calcium influx triggers apoptosis-like cascade leading to cell death.
Structure of AZD-1386
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
Structure of AMG-517
INHIBITOR -> TARGET
TRPV1 IC50 based on inhibition of calcium flux in response to 50 nM capsaicin in human TRPV1 stably expressed in human astrocytoma 1321 cells.
INHIBITOR
IC50
Structure of AM-404
AGONIST -> TARGET
Structure of ZUCAPSAICIN
MODULATOR->TARGET
Structure of AMG-628
INHIBITOR -> TARGET
INHIBITOR
IC50
Structure of JNJ-38893777
INHIBITOR -> TARGET
Structure of GRC-6211
INHIBITOR -> TARGET
Structure of V-116517
INHIBITOR -> TARGET
IC50
Structure of ABT-102
INHIBITOR -> TARGET
TRPV1 IC50 based on inhibition of calcium flux in response to 50 nM capsaicin in human TRPV1 stably expressed in human astrocytoma 1321 cells.
INHIBITOR
IC50
Structure of ASIVATREP
INHIBITOR -> TARGET
Structure of RESINIFERATOXIN
AGONIST -> TARGET
Structure of CMX-020
AGONIST -> TARGET
Structure of CAPSAICIN
AGONIST -> TARGET
Structure of DWP-05195
INHIBITOR -> TARGET
Structure of 7-HYDROXYCANNABIDIOL
AGONIST -> TARGET
Appears to be 5 times more active in preventing seizures than cannabidiol.
Structure of NORDIHYDROCAPSAICIN
AGONIST -> TARGET
9,100,000 Scoville units
Structure of SB-705498
INHIBITOR -> TARGET
INHIBITOR
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966