U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 17:41:03 GMT 2025
Edited
by admin
on Tue Apr 01 17:41:03 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
LGU8Z0A50H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAPSAICIN RECEPTOR
Preferred Name English
TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1
Common Name English
OTRPC1
Common Name English
TRPV1
Common Name English
VR1
Common Name English
OSM-9-LIKE TRP CHANNEL 1
Common Name English
VANILLOID RECEPTOR 1
Common Name English
Code System Code Type Description
PHAROS
Q8NER1
Created by admin on Tue Apr 01 17:41:03 GMT 2025 , Edited by admin on Tue Apr 01 17:41:03 GMT 2025
PRIMARY
UNIPROT
Q8NER1
Created by admin on Tue Apr 01 17:41:03 GMT 2025 , Edited by admin on Tue Apr 01 17:41:03 GMT 2025
PRIMARY
WIKIPEDIA
TRPV1
Created by admin on Tue Apr 01 17:41:03 GMT 2025 , Edited by admin on Tue Apr 01 17:41:03 GMT 2025
PRIMARY
FDA UNII
LGU8Z0A50H
Created by admin on Tue Apr 01 17:41:03 GMT 2025 , Edited by admin on Tue Apr 01 17:41:03 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_604
Related Record Type Details
Structure of DIHYDROCAPSAICIN
AGONIST -> TARGET
16,000,000 Scoville units same as Capsaicin
Structure of MOTUGIVATREP
INHIBITOR -> TARGET
Structure of ABT-102
INHIBITOR -> TARGET
Structure of MAVATREP
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
IC50
Structure of QX-314
ACTIVATOR -> TARGET
QX-314 directly activates TRPV1 and TRPA1 channels leading to a subsequent calcium influx (figs. 3A and 4A). It has been demonstrated that TRPV1-mediated calcium influx triggers apoptosis-like cascade leading to cell death.
Structure of AMG-628
INHIBITOR -> TARGET
Structure of AM-404
AGONIST -> TARGET
Structure of ZUCAPSAICIN
MODULATOR->TARGET
Structure of AMG-517
INHIBITOR -> TARGET
Structure of AZD-1386
INHIBITOR -> TARGET
Structure of JNJ-38893777
INHIBITOR -> TARGET
Structure of GRC-6211
INHIBITOR -> TARGET
Structure of V-116517
INHIBITOR -> TARGET
IC50
Structure of ASIVATREP
INHIBITOR -> TARGET
Structure of RESINIFERATOXIN
AGONIST -> TARGET
Structure of CMX-020
AGONIST -> TARGET
Structure of CAPSAICIN
AGONIST -> TARGET
Structure of DWP-05195
INHIBITOR -> TARGET
Structure of SB-705498
INHIBITOR -> TARGET
Structure of 7-HYDROXYCANNABIDIOL
AGONIST -> TARGET
Appears to be 5 times more active in preventing seizures than cannabidiol.
Structure of NORDIHYDROCAPSAICIN
AGONIST -> TARGET
9,100,000 Scoville units
Structure of SAR-115740
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_117] [1_775] [1_821] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_145] [1_371] [1_705] THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
NCATS
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