CAPSAZEPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21ClN2O2S
Molecular Weight	376.9
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC1=C(O)C=C2CN(CCCC2=C1)C(=S)NCCC3=CC=C(Cl)C=C3

InChI

InChIKey=DRCMAZOSEIMCHM-UHFFFAOYSA-N

InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)

HIDE SMILES / InChI

Molecular Formula	C19H21ClN2O2S
Molecular Weight	376.9
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Amiloride-sensitive sodium channel, ENaC 4	Activator 1,430		8.0 µM [EC50]
Vanilloid receptor 53	Antagonist 2,778		3.2 µM [Ki]

PubMed

Show entries

Title	Date	PubMed
Involvement of vanilloid receptors and purinoceptors in the Phoneutria nigriventer spider venom-induced plasma extravasation in rat skin.	2000 Mar 17	10729373
Pharmacology of airway afferent nerve activity.	2001	11686889
Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1.	2001	11226681
Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.	2001 Feb	11160509
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.	2001 Feb	11159715

Showing 1 to 5 of 16 entries

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Patents

Substance Class	Chemical
Record UNII	LFW48MY844
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

CAPSAZEPINE

Common Name

English

N-(2-(4-CHLOROPHENYL)ETHYL)-1,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-2H-2-BENZAZEPINE-2-CARBOTHIOAMIDE

Systematic Name

English

Showing 1 to 2 of 2 entries

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Code System

Code

Type

Description

WIKIPEDIA

Capsazepine

PRIMARY

MESH

C071423

PRIMARY

EPA CompTox

DTXSID20160852

PRIMARY

CAS

138977-28-3

PRIMARY

FDA UNII

LFW48MY844

PRIMARY

Showing 1 to 5 of 6 entries

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